1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC
50 = 3 nM) as well as Flt3 and cKit (IC
50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts
in vitro (IC
50 = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and
in vivo efficacy in a murine estradiol-induced uterine edema model (ED
50 = 4 mg/kg p.o. in balb/c mice).
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte