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Sincalid Produkt Beschreibung

Sincalide Struktur
25126-32-3
CAS-Nr.
25126-32-3
Bezeichnung:
Sincalid
Englisch Name:
Sincalide
Synonyma:
CCK-8;SQ-19844;Sincalid;SINCALIDE;SINCALIDE, >99%;Sincalid(CCK-8);CCK-8, SULFATED;CCK Octapeptide;Sincalide Acetate;SINCALIDE (CCK-8)
CBNumber:
CB7361692
Summenformel:
C49H62N10O16S3
Molgewicht:
1143.27
MOL-Datei:
25126-32-3.mol

Sincalid Eigenschaften

alpha 
D23 -18.4° (c = 0.7 in 1N NH3)
Dichte
1.440±0.06 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
0.05 M ammonium hydroxide: 1 mg/mL, clear, colorless
pka
-4.17±0.18(Predicted)
Aggregatzustand
powder
Wasserlöslichkeit
Soluble in water 1 g/L at 10°C.
Merck 
13,8617
BRN 
5231801

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3
8-10-21

Sincalid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Originator

Kinevac,Squibb,US,1976

Verwenden

Choleretic.

Manufacturing Process

The starting material in the following synthesis is: t-butyloxycarbonyl-Laspartyl- L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartyl-Lphenylalanine amide designated (SM)
.(A) A solution of (SM) (320 mg) in trifluoroacetic acid (7 ml) was kept under nitrogen at room temperature for 15 minutes. Ether (100 ml) was added and the precipitate filtered, washed thoroughly with ether and dried. This material (280 mg) was added to concentrated sulfuric acid (20 ml), cooled at -20°C. The solution was kept in the dry ice-acetone bath at -20°C for 75 minutes. The sulfuric acid solution was poured into ice water (80 ml). The precipitate was centrifuged, resuspended in ice water (30 ml) and 4N sodium hydroxide was added until a clear solution was obtained. After reacidification to pH 4 with dilute sulfuric acid, the precipitate formed was centrifuged, washed twice with ice water and dried. Yield 155 mg. Chromatograph of DEAE Sephadex (with ammonium carbonate buffer) yielded the desired octapeptide sulfate ester: 30 mg.
(B) A solution of (SM) (330 mg) in trifluoroacetic acid (7 ml) was kept under nitrogen at room temperature for 15 minutes. Ether (100 ml) was added and the precipitate was filtered, washed thoroughly with ether and dried. This material (300 mg) was added in portions to concentrated sulfuric acid (18 ml) cooled at -20°C with vigorous stirring. After 15 minutes a solution of potassium bisulfate in concentrated sulfuric acid (408 mg in 3 ml) was added. The reaction mixture was stirred for 75 minutes at -15°C and then stored at - 7°C for 285 minutes. The sulfuric acid solution was poured into cold ether (400 ml); precipitate was filtered, washed with cold ether, and suspended in cold water. Complete solution was then achieved by careful addition of 2N sodium hydroxide. Acidification with N hydrochloric acid led to the precipitation of the desired octapeptide sulfate ester. Yield 200 mg.

Trademarks

Kinevac (Bracco).

Therapeutic Function

Choleretic

Allgemeine Beschreibung

It was thought originally that cholecystokinin and pancreozyminwere two different hormones. Cholecystokinin wasthought to be responsible for contraction of the gallbladder,whereas pancreozymin was believed to induce secretion ofpancreatic enzymes. It is now clear that both actions arecaused by a single 33-residue polypeptide, referred to ascholecystokinin–pancreozymin (CCK-PZ). CCK-PZ is secretedin the blood in response to the presence of food in theduodenum, especially long-chain fatty acids. The fiveCOOH-terminal amino acid residues are identical with thosein gastrin. The COOH-terminal octapeptide retains full activityof the parent hormone.

Sincalid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sincalid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 148)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22624 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2712 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
BOC Sciences
1-631-619-7922 1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
Cellmano Biotech Limited
+86-551-65326643
+86-551-65326641 info@cellmano.com CHINA 1044 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7507 58

25126-32-3(Sincalid)Verwandte Suche:


  • SINCALIDE, >99%
  • Sincalide,CCK-8,SQ19844,Cholecystokinin octapeptide, >99%
  • (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-(methylthio)-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl
  • SINCALIDE (CCK-8)
  • Sincalide Acetate
  • Cholecystokinin C-terminal octapeptide
  • Cholecystokinin-pancreozymin
  • SQ-19844
  • CCK-8, Cholecystokinin octapeptide, Pancreozymin C-terminal octapeptide, Sincalide
  • Cholecystokinin, CCK Octapeptide (26-33)
  • Cholecystokinin Octapeptide, sulfated, CCK-8S
  • Sincalide H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
  • Cholecystokinin (26-33), CCK Octapeptide, sulfated
  • Cholecystokinin Octapeptide (sulfated) Sincalide, CCK-8 (sulfated), Cholecystokinin (26-33) (sulfated)
  • Sincalide, CCK-8 (sulfated), Cholecystokinin (26-33) (sulfated)
  • Sincalide ammonium salt
  • Cholecystokinin Octapeptide (sulfated),Sincalide
  • Sincalid
  • Sincalide (Kinevac)
  • PANCREOZYMIN C-TERMINAL OCTAPEPTIDE
  • SINCALIDE
  • (Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide
  • Sincalid(CCK-8)
  • (tyr(so3H)27)-cholecystokinin fragment*26-33 amid
  • H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2
  • H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM SALT
  • CHOLECYSTOKININ [TYR(SO3H)27]-FRAGMENT 26-33 AMIDE
  • CHOLECYSTOKININ, OCTAPEPTIDE (26-33), SULFATED
  • CHOLECYSTOKININ OCTAPEPTIDE (SULFATED)
  • CHOLECYSTOKININ OCTAPEPTIDE (SULFATED) AMMONIUM SALT
  • CHOLECYSTOKININ-8 (26-33), HUMAN, SULPHATED AMIDE
  • CHOLECYSTOKININ FRAGMENT 26-33 SULFATED
  • CHOLECYSTOKININ (26-33), SULFATED
  • CHOLECYSTOKININ (26-33) (SULFATED) AMMONIUM SALT
  • CCK OCTAPEPTIDE SULFATED
  • CCK, OCTAPEPTIDE (26-33), SULFATED
  • CCK-OCTAPEPTIDE (26-33) (SULFATED) AMMONIUM
  • CCK-OCTAPEPTIDE(26-33)(SULFATED FORM)
  • CCK OCTAPEPTIDE (CCK-8), SULFATED
  • CCK 26-33, SULFATED
  • CCK-8
  • CCK-8, SULFATED
  • CCK-8 (SULFATED) AMMONIUM
  • CCK-8 (SULFATED) AMMONIUM SALT
  • CCK-8 (26-33), HUMAN, SULPHATED AMIDE
  • D-Y(SO3H)-MGWMDF-NH2
  • ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2
  • ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM
  • [27-TYR(SO3H)]CHOLECYSTOKININ-FRAGMENT (26-33)-AMIDE
  • CCK Octapeptide
  • CCK-8;SQ-19844;CCK OCTAPEPTIDE
  • Cholecystokinin octapeptide
  • 25126-32-3
  • C49H62N10O16S2
  • C49H62N10O16S3
  • Gastrointestinal Products
  • Cholecystokinins
  • Peptides
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