Zolpidem tartrate
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- CAS-Nr.
- 99294-93-6
- Englisch Name:
- Zolpidem tartrate
- Synonyma:
- ambien;Myslee;Stilnox;ZOLPIDEM TARTRATE;L-(+)-Hemitartrate;ZOLPIDEM HEMITARTRATE;ZolMitriptan Tartrate;Zolpidem Tartrate Tablet;ZOLPIDEM TARTRATE EP C IV;AMBIEN(Zolpidem Tartrate)
- CBNumber:
- CB7451799
- Summenformel:
- C23H27N3O7
- Molgewicht:
- 457.48
- MOL-Datei:
- 99294-93-6.mol
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Zolpidem tartrate Eigenschaften
- Schmelzpunkt:
- 196 °C
- storage temp.
- 2-8°C
- Löslichkeit
- Slightly soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- BCS Class
- 1
- CAS Datenbank
- 99294-93-6(CAS DataBase Reference)
Zolpidem tartrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, hygroscopic, crystalline powder.
Verwenden
Sedativehypnotic.
Definition
ChEBI: The hemitartrate salt of zolpidem.
Pharmakokinetik
Zolpidem exhibits a high selectivity for the α1 subunit. Its good bioavailability of 72% and rapid onset of action
of approximately 1.4 hours following oral absorption can be attributed to its weak base (pKa = 6.2) and high
lipophilicity (mlog P = 3.85). Its pharmacokinetic profile is characterized by rapid absorption from the
gastrointestinal tract and a short elimination half-life because of rapid oxidative metabolism to inactive
carboxylic acid metabolites. Zolpidem undergoes CYP3A4 (major), CYP2DG, and CYP2D6
hydroxylation of the aryl methyl groups, followed by further oxidation by aldehyde
dehydrogenase to the ionic carboxylic acids, which are readily eliminated in the urine.
Zolpidem
demonstrates linear (dose-proportional) kinetics in the dose range of 5 to 20 mg. Although protein binding was
90%, no drug accumulation was observed following nightly dosing with 20-mg zolpidem tartrate tablets for 2
weeks. Food can prolong the time to peak concentration from 1.4 to 2.2 hours without affecting the half-life.
These results suggest that for faster sleep onset, zolpidem should not be administered with or immediately after
a meal. In the elderly, the dose should be 5 mg, because the elimination half-life is increased by 50% (from ~2
to ~3 hours). No accumulation was observed in elderly subjects following nightly oral dosing of 10 mg for 1
week. In patients with hepatic insufficiency, the plasma concentration doubled with an increase in the
elimination half-life from approximately 2 to approximately 10 hours (range, 4–25 hours). Therefore, dosing
should be modified in patients with hepatic insufficiency. No dosage adjustment should be necessary in patients
with compromised renal function. Zolpidem is not hemodialyzable, but it does cross the placenta and into breast
milk. Because of its longer elimination half-life (when compared to zaleplon), it may be preferred when sleep
maintenance is a primary concern.
Zolpidem tartrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Zolpidem tartrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 183)Lieferanten
99294-93-6()Verwandte Suche:
- N,N-Dimethyl-2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetamide 2,3-dihydroxysuccinate
- L-(+)-Hemitartrate
- ,r*))-2,3-dihydroxybutanedioate(2:1)
- 2-a)pyridine-3-acetamide,n,n,6-trimethyl-2-(4-methylphenyl)-imidazo((r-(r*
- ambien
- n,n,6-trimethyl-2-p-tolyl-imidazo(1,2-a)pyridine-3-acetamide l-(+)-tartrate (2:1)
- ZOLPIDEM HEMITARTRATE
- ZOLPIDEM TARTRATE
- Zolpidem tartrate solution
- Zolpidem Tartrate Tablet
- ZOLPIDEM TARTRATE EP C IV
- N,,6-Trimethyl-2-P-Tolyl-Imidazo(1,2-A)Pyridine-3-AcetamideL-(+)-Tartrate
- Imidazo1,2-apyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)
- Myslee
- Zolpidem Tartrate CIV (200 mg) (COLD SHIPMENT REQUIRED)
- ZolMitriptan Tartrate
- NYVVVBWEVRSKIU-UHFFFAOYSA-N
- AMBIEN(Zolpidem Tartrate)
- N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)-3-imidazo[1,2-a]pyridinyl]acetamide
- Zolpidem L-(+)-Hemitartrate
zolpidem tartrate
- N,N-dimethyl-2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetamide hemi((2R,3R)-2,3-dihydroxysuccinate)
- Zolpidem tartrate USP/EP/BP
- Stilnox
- ZolpidemTartarateQ: What is
ZolpidemTartarate Q: What is the CAS Number of
ZolpidemTartarate Q: What is the storage condition of
ZolpidemTartarate Q: What are the applications of
ZolpidemTartarate
- Zolpidem Tartrate(Z2500000)
- Zolpidem Tartrate CIV (COLD SHIPMENT REQUIRED) (1724907)
- Zolpidem L-(+)-hemitartrate
- 99294-93-6
- 2C19H21N3OC4H6O6
- C19H21N3OC4H6O6
- C19H21N3O12C4H6O6
- C4H6O62C19H21N3O
- C21H24N3O4
- Hypnotic
- Zolpidem
- Active Pharmaceutical Ingredients
- API
- 11
- 99294-93-6
