Difluprednat
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- CAS-Nr.
- 23674-86-4
- Bezeichnung:
- Difluprednat
- Englisch Name:
- Difluprednate
- Synonyma:
- DFBA;DUREZOL;w6309;myser;CM 9155;Epitopic;Difluprenate;DIFLUPREDNATE;Difluprednate-d3;Difluprednate-d5
- CBNumber:
- CB7458293
- Summenformel:
- C27H34F2O7
- Molgewicht:
- 508.55
- MOL-Datei:
- 23674-86-4.mol
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Difluprednat Eigenschaften
- Schmelzpunkt:
- 191-194°
- alpha
- D22 +31.7° (c = 0.5 in dioxane)
- Siedepunkt:
- 600.3±55.0 °C(Predicted)
- Dichte
- 1.1869 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Dioxane (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 12.56±0.70(Predicted)
- Farbe
- White
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
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| RTECS-Nr. |
TU3831500 |
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| HS Code |
2937.29.9095 |
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| Toxizität |
mouse,LD50,intraperitoneal,146mg/kg (146mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: FOOD INTAKE (ANIMAL),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 1066, 1984. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
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Difluprednat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Difluprednate is a synthetic glucocorticoid that potently activates the glucocorticoid receptor (K
i = 78 pM).
In vivo, ocular administration of difluprednate (0.05% w/v) increases intraocular pressure in sheep. Formulations containing difluprednate have been used to treat diabetic macular edema and inflammation following cataract surgery.
Chemische Eigenschaften
White Solid
Verwenden
Difluprednate-d3 is the isotope labeled form of Difluprednate (D445925), a corticosteroid (derivative of prednisolone), approved for the treatment of post-operative ocular inflammation.
Allgemeine Beschreibung
Difluprednate, 21-(acetyloxy)-6α,9-difluoro-11β-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione is being developed (phase III) as a topical ophthalmicemulsion to treat inflammatory eye diseases.
Difluprednat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Difluprednat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 195)Lieferanten
23674-86-4(Difluprednat)Verwandte Suche:
Vinylacetat
Ethylacetat
Glatiramer acetate
POLY(VINYL ACETATE)
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat
n-Butylacetat
Methylacetat
Testosteron
Diisobutylphthalat
Di(tert-butyl)carbonat
Dibutylsebacat
ufenamate
Natriumacetat
ACETATE
6α,9-Difluor-11β,17,21-trihydroxypregna-1,4-dien-3,20-dion
Isoflupredon-21-acetat
Difluprednat
5α-Pregnan
- 4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,17,21-trihydroxy-pregna-21-a
- 6-alpha,9-alpha-difluoroprednisolone17-butyrate21-acetate
- cetate,17-butyrate
- myser
- w6309
- 6a,9a-difluoroprednisolone 21-acetate 17-butyrate
- 6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE
- DIFLUPREDNATE
- 6α,9-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate
- 6α,9-Difluoroprednisolone 21-acetate 17-butyrate
- 6α,9α-Difluoroprednisolone 21-acetate 17-butyrate
- Butyric acid, 17-ester with 6α,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate (8CI)
- CM 9155
- Epitopic
- Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-, (6α,11β)-
- Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-, 21-acetate 17-butyrate (8CI)
- 6a,9-Difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate
- 21-Acetyloxy-6α,9-difluoro-11β-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione
- (6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-pregna-1,4-diene-3,20-dione
- 6a,9-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-Acetate 17-Butyrate
- Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-, (6a,11b)-
- Difluprednate-d3
- (6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion
- Difluprednate-d5
- Difluoroprednisolone butyrate acetate
- Difluprednate Solution, 100μg/mL
- Difluprednate USP/EP/BP
- Difluprednate(DFBA)
- (6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-pregna-1,4-diene-3,20-dione
- DifluprednateQ: What is
Difluprednate Q: What is the CAS Number of
Difluprednate Q: What is the storage condition of
Difluprednate Q: What are the applications of
Difluprednate
- DFBA
- DUREZOL
- [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
- Difluprenate
- cetate,Chemicalbook17-butyrate
- 6α,9α-Difluorprednisolon-17-butyrat-21-acetat
- 23674-86-4
- 23674-68-4
- C27H34F2O7
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- 23674-86-4
