Tacrin
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- CAS-Nr.
- 321-64-2
- Bezeichnung:
- Tacrin
- Englisch Name:
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- Synonyma:
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE;Tetrahydroaminoacridine;C01453;acrine;cs12602;CS 12602;AKOS 221-09;Tacrine 321-64-2;BUTTPARK 20\04-06;Tetrahydroaminocrin
- CBNumber:
- CB7699634
- Summenformel:
- C13H14N2
- Molgewicht:
- 198.26
- MOL-Datei:
- 321-64-2.mol
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Tacrin Eigenschaften
- Schmelzpunkt:
- 183.5℃
- Siedepunkt:
- 325.59°C (rough estimate)
- Dichte
- 0.9827 (rough estimate)
- Brechungsindex
- 1.4400 (estimate)
- storage temp.
- 4°C, away from moisture and light
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 9?+-.0.20(Predicted)
- Farbe
- White to Pale Yellow
- CAS Datenbank
- 321-64-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Tacrin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In the 1950s, tacrine was used experimentally to reverse
cholinergic coma in animals. In the 1960s, tacrine was used to
reverse the effects of phencyclidine-like drugs. It was also
marketed for many years as a respiratory stimulant. In 1993,
the US Food and Drug Administration approved tacrine for the
treatment of symptoms of mild to moderate Alzheimer’s
disease.
Verwenden
The current use of tacrine is limited due to its poor oral
bioavailability, the necessity for four daily doses, and serious
side effects (including nausea, vomiting, dry mouth, indigestion,
diarrhea, loss of appetite, urinary incontinence, collapse,
convulsions, and hepatotoxicity). Currently, newer cholinesterase
inhibitors (such as donepezil, rivastigmine, and galantamine)
are preferred over tacrine.
Tacrin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tacrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 115)Lieferanten
321-64-2(Tacrin)Verwandte Suche:
- 1,2,3,4-tetrahydro-9-acridinamin
- 1,2,3,4-tetrahydro-9-amino-acridin
- 1,2,3,4-Tetrahydro-9-aminoacridine
- 5-Amino-6,7,8,9-tetrahydroacridine
- Acridine, 1,2,3,4-tetrahydro-9-amino-
- Acridine, 9-amino-1,2,3,4-tetrahydro-
- Acridine, 9-aminotetrahydro-
- CS 12602
- cs12602
- Tetrahydroaminacrine
- Tetrahydroaminocrin
- Tetrahydroaminocrine
- BUTTPARK 20\04-06
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- 9-AMINOTETRAHYDROACRIDINE
- AKOS 221-09
- TIMTEC-BB SBB003560
- 1,2,3,4-tetrahydroacridin-9-amine
- Tacrine (base and/or unspecified salts)
- 1,2,3,4-Tetrahydro-acridin-9-ylamine
- C01453
- Tacrine 321-64-2
- 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate, 97%
- 9-AcridinaMine, 1,2,3,4-tetrahydro-
- 1,2,3,4-Tetrahydro-5-aminoacridine
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE USP/EP/BP
- Tetrahydroaminoacridine
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE
- acrine
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE，HPLC≥97%
- 321-64-2
- C13H14N2HClH2O
