Deferasirox

Deferasirox Struktur
201530-41-8
CAS-Nr.
201530-41-8
Englisch Name:
Deferasirox
Synonyma:
20kg;Exjade;4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid;ICL-670;Delarox;CGP-72670;eferasirox;deferasirox;Deferisirox;Deferasirox D8
CBNumber:
CB7855359
Summenformel:
C21H15N3O4
Molgewicht:
373.36
MOL-Datei:
201530-41-8.mol

Deferasirox Eigenschaften

Schmelzpunkt:
260-2620C
Siedepunkt:
672.1±65.0 °C(Predicted)
Dichte
1.40±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit
Soluble in DMSO (10 mg/ml)
Aggregatzustand
solid
pka
pKa1 4.57, pKa2 8.71, pKa3 10.56 (Nick); Also reported in H2O/DMSO (CDMSO = 0.20) as pKa1 4.61, pKa2 10.12, pKa3 12.08 (Steinhauser)
Farbe
Off-white to white
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2933997500
Giftige Stoffe Daten 201530-41-8(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P391 Verschüttete Mengen aufnehmen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Deferasirox Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Linagliptin was originally discovered at Boehringer Ingelheim as an orally active dipeptidyl peptidase-IV (DPP-4) inhibitor. Eli Lilly and Boehringer Ingelheim co-developed and launched linagliptin for type II diabetes as an adjunct to diet and exercise for the improvement of adult glycemic control. Linagliptin has a superior DPP-4 IC50 value of 1 nM, compared with 19 nM for sitagliptin, 24 nM for alogliptin, 50 nM for saxagliptin and 62 nM for vildagliptin. In addition, linagliptin exhibited prolonged pharmacodynamic activity with long-lasting DPP-4 inhibition in several preclinical species. Linagliptin showed good efficacy in phase II clinical trials with doses as low as 5 mg and no signs of hypoglycemia with doses as high as 600 mg. The prolonged pharmacological effect of DPP-4 activity and the good safety/tolerability profile provided the basis for linagliptin’s approval.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Biological Activity Chemical Information Tech Support & FAQs Biological Activity Deferasirox(Exjade) is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions

Definition

ChEBI: A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patient receiving long-term blood transfusions.

Deferasirox Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Deferasirox Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 400)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Dangtong Import and export Co LTD
+8615632927689
admin@hbdangtong.com China 998 58
Shanghai Affida new material science and technology center
+undefined15081010295
2691956269@qq.com China 349 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 967 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58

201530-41-8()Verwandte Suche:


  • Deferasirox(CGP-72670)
  • Deferasirox(Exjade)
  • 4-[3,5-bis(2-hydroxyphenyl)
  • Deferasirox, >=99%
  • Deferasirox D8
  • 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
  • deferasirox
  • Deferasirox for research
  • 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid
  • CGP-72670
  • ICL-670
  • Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-
  • Deferasirox D8Q: What is Deferasirox D8 Q: What is the CAS Number of Deferasirox D8 Q: What is the storage condition of Deferasirox D8 Q: What are the applications of Deferasirox D8
  • Deferasirox for system suitability (Y0002197)Q: What is Deferasirox for system suitability (Y0002197) Q: What is the CAS Number of Deferasirox for system suitability (Y0002197)
  • DeferasiroxQ: What is Deferasirox Q: What is the CAS Number of Deferasirox Q: What is the storage condition of Deferasirox Q: What are the applications of Deferasirox
  • 4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoicaChemicalbookcid
  • Deferisirox
  • Decitabine USP RC C
  • [14C]Deferasirox
  • [14C]4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
  • 4-[bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
  • Deferasirox USP/EP/BP
  • Deferasirox (ICL 670)
  • 4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
  • 20kg
  • Exjade
  • Deferasirox Deferasirox(API)
  • eferasirox
  • Delarox
  • Deferasirox (200 mg)
  • 201530-41-8
  • 530-41-8
  • 140891-02-6
  • C21H15N3O4
  • Pharmaceutical intermediate
  • Aromatics
  • Chelating Agents & Ligands
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Exjade, ICL-670, ICL-670A, CGP-72670
  • Chelating agent (iron)
  • Aromatics Compounds
  • 1
Copyright 2019 © ChemicalBook. All rights reserved