Conivaptan hydrochloride
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- CAS-Nr.
- 168626-94-6
- Englisch Name:
- Conivaptan hydrochloride
- Synonyma:
- Vaprisol;Conivaptan HCI;Conivaptan HCl;Unii-75L57R6X36;Conivaptan HCl (YM 087);Conivaptan hydrochkoride;Conivaptan hydrochloride;Conivaptan hydrochloride [usan];Conivaptan hydrochloride, >=99%;Conivaptan hydrochloride USP/EP/BP
- CBNumber:
- CB81246922
- Summenformel:
- C32H26N4O2.HCl
- Molgewicht:
- 535.04
- MOL-Datei:
- 168626-94-6.mol
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Conivaptan hydrochloride Eigenschaften
- Schmelzpunkt:
- >250°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChIKey
- BTYHAFSDANBVMJ-UHFFFAOYSA-N
- SMILES
- C12=CC=CC=C1N(CCC1N=C(C)NC2=1)C(=O)C1=CC=C(NC(=O)C2C=CC=CC=2C2=CC=CC=C2)C=C1.Cl
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
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Conivaptan hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Arginine vasopressin is intimately involved in volume homeostasis, and
elevated levels of arginine vasopressin are responsible for the pathogenesis and
progression of diseases with an imbalance of sodium and water, particularly
congestive heart failure. To restore homeostasis, antagonism of vasopressin
receptors is a practical solution. As such, conivaptan has been developed and
launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive,
reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular
resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth
muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2
receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum
sodium concentration and reducing total body volume. Currently, the drug is
approved for the management of refractory hyponatremia and potentially lifethreatening
sodium and water imbalance, but it has shown promise as a potential
treatment option for other diseases, such as congestive heart failure, syndrome of
antidiuretic hormone, diabetes insipidus, and liver cirrhosis.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).
Definition
ChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau
ed by syndrome of inappropriate antidiuretic hormone (SIADH).
Conivaptan hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Conivaptan hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 184)Lieferanten
- (1,1'-Biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-, monohydrochloride
- Conivaptan HCl
- Conivaptan hydrochloride [usan]
- Unii-75L57R6X36
- Vaprisol
- Conivaptan hydrochkoride
- N-[4-[(4,5-Dihydro-2-MethyliMidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxaMide Hydrochloride
- Conivaptan HCI
- N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide, hydrochloride (1:1)
- [1,1'-Biphenyl]-2-carboxamide,N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-,hydrochloride
- Conivaptan hydrochloride, >=99%
- Conivaptan hydrochloride
- N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride
- N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamid
- N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
- N-(4-(2-methyl-3,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride
- 1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, hydrochloride (1:1)
- Conivaptan hydrochloride USP/EP/BP
- Conivaptan HCl (YM 087)
- Conivaptan HydrochlorideQ: What is
Conivaptan Hydrochloride Q: What is the CAS Number of
Conivaptan Hydrochloride Q: What is the storage condition of
Conivaptan Hydrochloride Q: What are the applications of
Conivaptan Hydrochloride
- Vaprisol, Conivaptan hydrochloride
- N-(4-(2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride
- N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide hydrochloride
- 168626-94-6
- C32H26N4O2HCl
- C32H27ClN4O2
- Inhibitors
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
