2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC
50 values of 1,837, 25, 631, 317, and 393 μM for M
1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M
2-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC
50 = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC
50 = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Chemische Eigenschaften
White Solid
Verwenden
cholinergic
Definition
ChEBI: The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and
as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Allgemeine Beschreibung
Bethanechol, β-methylcholinechloride carbamate, (2-hydroxypropyl)trimethylammoniumchloride carbamate, carbamylmethylcholinechloride (Urecholine), is nonspecific in its action on muscarinicreceptor subtypes but appears to be more effective ateliciting pharmacological action of M3 receptors. It haspharmacological properties similar to those of methacholine.Both are esters of β-methylcholine and have feeblenicotinic activity. Bethanechol is inactivated more slowlyby AChE in vivo than is methacholine. It is a carbamyl esterand is expected to have stability in aqueous solutions similarto that of carbachol.
Hazard
Headache, flushing, gastrointestinal distress, diarrhea, hypotension, excessive salivation, sweating, hypersensitivity.
Mechanism of action
Bentanechol is a drug, which has structurally unique qualities of both methacholine and
carbachol, i.e. it contains both β-methyl and carbamate functional groups, and quite
logically exhibits pharmacological properties of both the drugs. It is resistant to hydrolysis by cholinesterases and has a very minor effect on nicotinic receptors of the
autonomic ganglia and neuromuscular junctions. Betanechol has more of a selective
action on muscarinic receptors of the gastrointestinal tract and the bladder than do other
cholinic esters.
Clinical Use
The main use of bethanechol chloride is in the relief ofurinary retention and abdominal distention after surgery.The drug is used orally and by subcutaneous injection. Itmust never be administered by intramuscular or intravenousinjection because of the danger from cholinergic overstimulationand loss of selective action. Proper administration ofthe drug is associated with low toxicity and no serious sideeffects. Bethanechol chloride should be used with caution inasthmatic patients; when used for glaucoma, it producesfrontal headaches from the constriction of the sphinctermuscle in the eye and from ciliary muscle spasms. Its durationof action is 1 hour.
2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propan-aminiumchlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
