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Sodium dihydrogen phosphate dihydrate Produkt Beschreibung

Sodium dihydrogen phosphate dihydrate Struktur
13472-35-0
CAS-Nr.
13472-35-0
Englisch Name:
Sodium dihydrogen phosphate dihydrate
Synonyma:
SAMARIUM 1,000PPM;SODIUM BIPHOSPHATE;Sodium dihydrogen ph;Natriumdihydrogenphosphat;SODIUM PHOSPHATE 1BAS 2HYD;SODIUM PHOSPHATE DIHYDRATE;MONO-SODIUM ORTHOPHOSPHATE;Sodiumdihydrogenphosphate,di;SODIUM BIPHOSPHATE DIHYDRATE;SODIUM PHOSPHATE MONOBASIC 2H2O
CBNumber:
CB8203308
Summenformel:
H6NaO6P
Molgewicht:
156.01
MOL-Datei:
13472-35-0.mol

Sodium dihydrogen phosphate dihydrate Eigenschaften

Schmelzpunkt:
60 °C
Dichte
1,915 g/cm3
storage temp. 
Store at +5°C to +30°C.
Löslichkeit
H2O: 1 M at 20 °C, clear, colorless
Aggregatzustand
Solid
Farbe
White
Geruch (Odor)
Odorless
PH
4.0-4.5 (25℃, 50mg/mL in H2O)
Säure-Base-Indikators(pH-Indikatoren)
4.2 - 4.5
Wasserlöslichkeit
SOLUBLE
maximale Wellenlänge (λmax)
λ: 260 nm Amax: 0.085
λ: 280 nm Amax: 0.070
Sensitive 
Hygroscopic
Merck 
14,8660
Stabilität:
Stable.
InChIKey
VBJGJHBYWREJQD-UHFFFAOYSA-M
CAS Datenbank
13472-35-0(CAS DataBase Reference)
EPA chemische Informationen
Phosphoric acid, monosodium salt (13472-35-0)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36-36/37/38
S-Sätze: 39-26-24/25-36
WGK Germany  1
RTECS-Nr. WA1900500
TSCA  Yes
HS Code  2835 22 00
Toxizität LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg

Sodium dihydrogen phosphate dihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S39:Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

white crystalline solid

Chemische Eigenschaften

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Vorbereitung Methode

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

Pharmazeutische Anwendungen

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

Sicherheit(Safety)

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

Lager

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

Inkompatibilitäten

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium dihydrogen phosphate dihydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sodium dihydrogen phosphate dihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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13472-35-0()Verwandte Suche:


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