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Aripiprazole

Aripiprazole Struktur
129722-12-9
CAS-Nr.
129722-12-9
Englisch Name:
Aripiprazole
Synonyma:
ABILIFY;ARIPIPRAZOLE-D8;Arpiprazole;Aripirazole;OPC 31;ABILITAT;OPC 14597;Abilify-d8;OPC 31-d8-;Abilitat-d8
CBNumber:
CB8210870
Summenformel:
C23H27Cl2N3O2
Molgewicht:
448.39
MOL-Datei:
129722-12-9.mol
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Aripiprazole Eigenschaften

Schmelzpunkt:
139°C
Siedepunkt:
646.2±55.0 °C(Predicted)
Dichte
1.263±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: soluble5mg/mL, clear (warmed)
pka
14.42±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Merck 
14,785
BCS Class
2
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
CEUORZQYGODEFX-UHFFFAOYSA-N
CAS Datenbank
129722-12-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,Xn
R-Sätze: 11-20/21/22-36
S-Sätze: 16-36/37
RIDADR  UN 1993C 3 / PGIII
WGK Germany  3
RTECS-Nr. VC8275950
HS Code  29349990
Giftige Stoffe Daten 129722-12-9(Hazardous Substances Data)
Toxizität TDLo ivn-dog: 0.03 mg/kg/10M TXAPA9 173,120,2001
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P233 Behälter dicht verschlossen halten.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

Aripiprazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Colourless Flake Crystalline Solid

Verwenden

A deuterated version of Aripiprazole, a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Please note that users have reported separation of this compound and aripiprazole under normal-phase and reverse-phase

Allgemeine Beschreibung

Aripiprazole (Abilify). The newest, longactingaripiprazole (an arylpiperazine quinolinone derivative),appears to be partial agonist of D2 receptors (i.e., itstimulates certain D2 receptors while blocking others dependingon their locations in the brain and the concentrationof drug). Bioavailability of aripiprazole is around 87%, with peak plasma concentration attained at 3 to 5 hours afterdosing. It is metabolized by dehydrogenation, oxidative hydroxylation, and N-dealkylation, largelymediated by hepatic CYPs 3A4 and 2D6.
The diphenylbutylpiperidine class can be considered amodification of the fluorobutyrophenone class. Because oftheir high lipophilicity, the compounds are inherently longacting. Pimozide has been approved for antipsychotic use,and penfluridol has undergone clinical trials in the UnitedStates. Overall, side effects for the two compounds resemblethose produced by the fluorobutyrophenones.

Hazard

A poison.

Sicherheitsprofil

A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and Cl-.

Aripiprazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3-Chloranilin 1,4-Dibrombutan N,N-Diethylethanamin 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Aripiprazole hydrochloride 2(1H)-Quinolinone, 3,4-dihydro-7-(2-propen-1-yloxy)- 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone 1-(2,3-Dichlorophenyl)-piperazine

Downstream Produkte

DEHYDRO ARIPIPRAZOLE

Aripiprazole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 658)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou Rokechem Technology Co., Ltd.
18758118018
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Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613
 Sara@xmwonderfulbio.com China 305 58
Guangzhou Tengyue Chemical Co., Ltd. 		+86-86-18148706580 +8618826483838
 evan@tyvovo.com China 152 58
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 admin@guyunchem.com China 616 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9352 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3012 60
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763
 info@tnjchem.com China 2989 55
Shanxi Naipu Import and Export Co.,Ltd 		+86-13734021967 +8613734021967
 kaia@neputrading.com China 1011 58

129722-12-9()Verwandte Suche:

2-Piperazin-1-ylethanol [[p-(2-Methoxyethyl)phenoxy]methyl]oxiran 1-(2-Chlorphenyl)piperaziniumchlorid
  • ARIPIPRAZOLE
  • ABILITAT
  • 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
  • OPC 14597
  • OPC 31
  • 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
  • OPC-14597, OPC-31,
  • 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
  • Form I of Aripiprazole
  • Aripiprazole solution
  • Aripiprazole (200 mg)
  • Aripiprazole, >=99%
  • Alipiprazole
  • 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydro-2(1H)-quinolinone
  • 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydrocarbostyril
  • Abilify-d8
  • Abilitat-d8
  • OPC 14597-d8
  • OPC 31-d8-
  • 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydrocarbostyril
  • 2(1H)-Quinolinone, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-
  • 7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
  • Aripiprozole
  • Aripiprazole (Abilify)
  • Aripiprazole Tablets
  • Aripiprazole (Both tablet and inj grade)
  • 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one
  • Crystal forms reference substance of Aripiprazole
  • Form II of Aripiprazole
  • Form C of Aripiprazole
  • Form B of Aripiprazole
  • Aripiprazole Form I
  • Aripiprazole Form II
  • Aripiprazole Form A
  • Aripiprazole Form B
  • Aripiprazole Form C
  • Aripiprazole Form D
  • Aripiprazole Form E
  • Aripiprazole Form F
  • Aripiprazole Form G
  • Aripiprazole, 98%, a human 5-HT1A receptor partial agonist
  • Aripiprazole Manufacturer
  • Aripiprazole >
  • Aripiprazole CRS
  • Aripiprazole USP/EP/BP
  • Aripiprazole (OPC-14597)
  • AripiprazoleQ: What is Aripiprazole Q: What is the CAS Number of Aripiprazole Q: What is the storage condition of Aripiprazole Q: What are the applications of Aripiprazole
  • TIANFU-CHEM CAS:129722-12-9 Aripiprazole
  • Aripiprazole (1042634)
  • ARIPIPRAZOLE-D8
  • ABILIFY
  • Arpiprazole
  • Aripirazole
  • Aripiprazole Type 1
  • Aripirazole (USP)
  • Aripiprazole 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4- dihydroquinolin-2(1H)-one
  • 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrChemicalbookocarbostyril
  • 129722-12-9
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