Linaclotide

Linaclotide Struktur
851199-59-2
CAS-Nr.
851199-59-2
Englisch Name:
Linaclotide
Synonyma:
Linacllotide;Rinalodipine Acetate;CY-14;Argpessin;Liclotide;inaclotide;Linaclotide;Linaelotide;Linaelotide Acetate;Linaclotide USP/EP/BP
CBNumber:
CB82498818
Summenformel:
C59H79N15O21S6
Molgewicht:
1526.74
MOL-Datei:
851199-59-2.mol

Linaclotide Eigenschaften

Schmelzpunkt:
231-235°C (dec.)
Siedepunkt:
2045.0±65.0 °C(Predicted)
Dichte
1.60
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
Löslichkeit
DMSO (Slightly, Heated), Methanol ((Slightly, Heated)), Water (Slightly, Heated)
pka
3.05±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White
Stabilität:
Hygroscopic
InChIKey
KXGCNMMJRFDFNR-VRMHCMCOSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Linaclotide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.

Verwenden

Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.

Biologische Funktion

Linaclotide works by increasing fluid in your intestines and helping speed up movement of food through the gut. Linaclotide may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements.

Nebenwirkungen

Side effects include:Diarrhea, abdominal pain, flatulence, abdominal distension, viral gastroenteritis, headache, upper respiratory tract infection, sinusitis

Linaclotide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Linaclotide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 271)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hantai Biomedical Group Co. LTD
+8618819265912
id002@cnhantide.com China 37 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58
Apextide Co Ltd
+undefined15700198315
senjie.hou@sinopep.com China 71 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12457 58
ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
+8619155187336
shengzhikai3@shengzhikai.com China 38 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5993 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 11013 58
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412
sales@alphabiopharm.com China 886 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21695 55
Rixing Chemical CO.,LTD
+86-13237129059 -13237129059
sales@rixingchemi.com CHINA 229 55

851199-59-2()Verwandte Suche:


  • Linaclotide
  • Linaelotide Acetate
  • Linaelotide
  • CY-14
  • Liclotide
  • Argpessin
  • L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
  • Linaclotide USP/EP/BP
  • L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosylChemicalbook-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
  • Linaclotide D4Q: What is Linaclotide D4 Q: What is the CAS Number of Linaclotide D4 Q: What is the storage condition of Linaclotide D4 Q: What are the applications of Linaclotide D4
  • inaclotide
  • Linacllotide
  • Rinalodipine Acetate
  • Linaclotide/Linaelotide Acetate
  • 851199-59-2
  • C59H79N15O21S6
  • C59H78N16O22S6
  • Inhibitors
  • 851199-59-2
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