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GZD 824

GZD 824 Struktur
1257628-77-5
CAS-Nr.
1257628-77-5
Englisch Name:
GZD 824
Synonyma:
GZD824;GZD8824;GZD-824;GZD 824;GZD-824 Free;Olverembatinib;GZD 824 USP/EP/BP;GZD824;GZD-824;GZD 824;Olverembatinib (GZD824);GZD-824; GZD 824;BENZAMIDE
CBNumber:
CB82666626
Summenformel:
C29H27F3N6O
Molgewicht:
532.56
MOL-Datei:
1257628-77-5.mol
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GZD 824 Eigenschaften

Siedepunkt:
630.4±55.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO : ≥ 100 mg/mL (187.77 mM)
Aggregatzustand
A crystalline solid
pka
9.04±0.40(Predicted)

Sicherheit

GZD 824 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.

Verwenden

GZD824 is a orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) kinases. It is a COVID19-related research product.

GZD 824 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Pyrazolo[3,4-b]pyridine, 5-[2-(trimethylsilyl)ethynyl]- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE 4-b]pyridine METHYL 3-IODO-4-METHYLBENZOATE

Downstream Produkte

GZD 824 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 92)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853
sales@tianpharm.com CHINA 304 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28180 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29322 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9923 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9991 58
  • 4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
  • 3-(2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
  • GZD8824
  • GZD824;GZD-824;GZD 824
  • GZD-824 Free
  • GZD 824
  • GZD824
  • GZD-824
  • GZD-824; GZD 824;BENZAMIDE
  • Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-
  • GZD 824 USP/EP/BP
  • 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
  • Olverembatinib
  • Olverembatinib (GZD824)
  • 1257628-77-5
  • 257628-77-5
  • Inhibitors
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