I-CBP112

1640282-31-0

CAS-Nr.: 1640282-31-0

Englisch Name:: I-CBP112

Synonyma:: CS-2420;I-CBP112;I-CBP112, >98%;I-CBP112 hydrochloride;I-CBP112, 1640282-31-0;I-CBP112; I-CBP-112; I-CBP 112;I-CBP112,Inhibitor,HATs,I CBP112,inhibit,I-CBP-112,HAT,ICBP112,Epigenetic Reader Domain,Histone Acetyltransferase;1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methyl-3-piperidyl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one;1-Propanone, 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-;1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one

CBNumber:: CB82714666

Summenformel:: C27H36N2O5

Molgewicht:: 468.59

MOL-Datei:: 1640282-31-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 72

I-CBP112 Eigenschaften

Siedepunkt:: 623.5±55.0 °C(Predicted)

Dichte: 1.129±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO:63.0(Max Conc. mg/mL);134.44(Max Conc. mM)
Ethanol:94.0(Max Conc. mg/mL);200.6(Max Conc. mM)
Water:94.0(Max Conc. mg/mL);200.6(Max Conc. mM)

pka: 9.07±0.10(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

RIDADR	UN 3077 9 / PGIII
WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H410	Sehr giftig für Wasserorganismen mit langfristiger Wirkung.	Langfristig (chronisch) gewässergefährdend	Kategorie 1	Warnung	src="/GHS09.jpg" width="20" height="20" />	P273, P391, P501

Sicherheit

P273	Freisetzung in die Umwelt vermeiden.
P501	Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

I-CBP112 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

I-CBP112 has been used in cell culture and sample preparation, to verify the acetylation of VPS34 (vacuolar protein sorting 34), by p300 at K29, K771 and K781 and to diminish synergistic gene expression.

Biochem/physiol Actions

I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please see I-CBP112 on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

I-CBP112 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

I-CBP112 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 72)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

I-CBP112
1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one
I-CBP112, 1640282-31-0
I-CBP112 hydrochloride
I-CBP112, >98%
I-CBP112; I-CBP-112; I-CBP 112
CS-2420
1-Propanone, 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-
I-CBP112,Inhibitor,HATs,I CBP112,inhibit,I-CBP-112,HAT,ICBP112,Epigenetic Reader Domain,Histone Acetyltransferase
1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methyl-3-piperidyl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one
1640282-31-0