Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

5184-64-5

CAS-Nr.: 5184-64-5

Englisch Name:: Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Synonyma:: ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05

CBNumber:: CB83290819

Summenformel:: C16H18O2S

Molgewicht:: 274.38

MOL-Datei:: 5184-64-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 25

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Eigenschaften

Schmelzpunkt:: 119-120 °C

Siedepunkt:: 426.7±45.0 °C(Predicted)

Dichte: 1.129±0.06 g/cm3(Predicted)

storage temp.: room temp

Löslichkeit: DMSO: soluble

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

Biochem/physiol Actions

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 25)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3412	55
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Wuxi Kehua Biological Technology Co., Ltd.	0510-0510-86838766	2258830676@qq.com	China	3822	58

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
MESITYL P-TOLYL SULFONE
ESI-05
ESI-05 (ESI05)
1,3,5-trimethyl-2-tosylbenzene
NSC 116966
ESI-05 >=98% (HPLC)
ESI-05 (NSC 116966)
Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05
5184-64-5