Dolasetron mesylate

Dolasetron mesylate Struktur
115956-13-3
CAS-Nr.
115956-13-3
Englisch Name:
Dolasetron mesylate
Synonyma:
anzemet;mdl73147ef;Anzemet hydrate;DOLASETRON MESYLATE;Dalasetron (Mesylate);Dolasetron Mesylate USP;Dolasetron Mesylate hydrate;Dolasetron Mesylate (200 mg);DOLASETRON MESYLATE MONHYDATE;dolasetronmesylatemonohydrate
CBNumber:
CB8341693
Summenformel:
C20H26N2O7S
Molgewicht:
438.49
MOL-Datei:
115956-13-3.mol

Dolasetron mesylate Eigenschaften

Schmelzpunkt:
278°
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
H2O: >30mg/mL
Aggregatzustand
powder
Farbe
white to off-white
CAS Datenbank
115956-13-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Dolasetron mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dolasetron was launched as Anzemet in Australia and the US for the prevention of nausea and vomiting in chemotherapy patients. It is a highly potent and very selective antagonist of 5-HT3 receptors ; it is the sixth in this class of compounds to be marketed for the treatment of chemotherapy-induced emesis. The last two approved in this class were Nazasetron (1994) and Ramosetron (1996). Anzemet was prepared by a seven step sequence from a cyclopentenecarboxylic ester via a Robinson-Schopf cyclisation of a dialdehyde into a key 9-azabicyclo[3.3.l]nonan-3-one. In a clinical study with 164 cancer patients treated with Dolasetron mesylate prior to Cisplatin, single doses of 10- 50 mg achieved major control of nausea and emesis in 73% of subjects and were well tolerated. Results from pharmacokinetic studies in humans showed that the clinical effects and duration of action seem to be due mainly to a major plasma metabolite rapidly formed and very potent itself, the (+) enantiomeric alcohol obtained by enzymatic reduction of the cyclic ketone.

Verwenden

Dolasetron Mesylate acts as a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.

Dolasetron mesylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dolasetron mesylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 153)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2504 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290
1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17368 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58

115956-13-3()Verwandte Suche:


  • DOLASETRON MESYLATE:DOLASETRON
  • Dolasetron mesylate/(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate
  • (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate
  • Dolasetron Mesylate (200 mg)
  • Dolasetron Mesylate hydrate
  • Dalasetron (Mesylate)
  • Anzemet hydrate
  • Dolasetron methanesulfonate hydrate
  • Dolasetron Mesylate USP
  • DOLASETRON MESYLATE
  • DOLASETRON MESYLATE MONHYDATE
  • 1h-indole-3-carboxylicacid,octahydro-3-oxo-2,6-methano-2h-quinolizin-8-ylest
  • dolasetronmesylatemonohydrate
  • er,(2-alpha,6-alpha,8-alpha,9a-beta)-,monomethanesulfonate,monohydrate
  • mdl73147ef
  • Dolasetron mesylate (MDL73147)
  • Dolasetron mesylate USP/EP/BP
  • 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
  • anzemet
  • 115956-13-3
  • 15956-13-3
  • 115953-13-3
  • C20H26N2O7S
  • C19H20N2O3CH4O3SH2O
  • C20H24N2O6S
  • C19H20N2O3CH4O3S
  • API
  • Other APIs
  • Antiemetic
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