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ChemicalBook > Produktkatalog >Katalysatoren und Additive >Antioxidantien >2,6-Di-tert-butyl-p-kresol

2,6-Di-tert-butyl-p-kresol Produkt Beschreibung

Englisch Name:Butylated Hydroxytoluene
p21;BHT;ao4k;ao29;BUKS;SDI1;cao1;cao3;DBMP;P 21
2,6-Di-tert-butyl-p-kresol physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 69-73 °C(lit.)
Siedepunkt:: 265 °C(lit.)
Dichte: 1.048
Dampfdichte: 7.6 (vs air)
Dampfdruck: <0.01 mm Hg ( 20 °C)
Brechungsindex: 1.4859
Flammpunkt:: 127 °C
storage temp. : 0-6°C
Löslichkeit: methanol: 0.1 g/mL, clear, colorless
Aggregatzustand: Crystals
pka: pKa 14(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
Farbe: white
Wasserlöslichkeit: insoluble
Merck : 14,1548
BRN : 1911640
Stabilität:: Stable, but light-sensitive. Incompatible with acid chlorides, acid anhydrides, brass, copper, copper alloys, steel, bases, oxidizing agents. Combustible.
CAS Datenbank: 128-37-0(CAS DataBase Reference)
NIST chemische Informationen: Butylated hydroxytoluene(128-37-0)
EPA chemische Informationen: Phenol, 2,6-bis(1,1-dimethylethyl)- 4-methyl-(128-37-0)
Kennzeichnung gefährlicher: Xn,N
R-Sätze:: 22-36/37/38-36/38-50/53
S-Sätze:: 26-36-37/39-61-60
RIDADR : 3077
WGK Germany : 1
RTECS-Nr.: GO7875000
F : 8-10-23
Selbstentzündungstemperatur: 878 °F
TSCA : Yes
HazardClass : 9
PackingGroup : III
HS Code : 29071900
Giftige Stoffe Daten: 128-37-0(Hazardous Substances Data)
Toxizität: LD50 orally in mice: 1040 mg/kg (McOmie)

2,6-Di-tert-butyl-p-kresol Chemische Eigenschaften,Einsatz,Produktion Methoden

Zersetzung beim Verbrennen und bei Kontakt mit oxidierenden Substanzen.
TLV: (Einatembare Fraktion und Dampf) 2 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK: 20 mg/m?(Einatembare Fraktion) Spitzenbegrenzung: überschreitungsfaktor II(2); Krebserzeugend Kategorie 4; Schwangerschaft: Gruppe C; (DFG 2008).
Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.
Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein
Die Substanz reizt die Augen und die Haut.
Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen. Möglich sind Auswirkungen auf die Leber.
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
white crystalline solid
Chemische Eigenschaften
BHT is a white to pale yellow crystalline solid or powder.
Chemische Eigenschaften
Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.
Chemische Eigenschaften
BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. BHT has a very faint, musty, occasional cresylictype odor. BHA and BHT are extensively used in foods as antioxidants. Most fats, oils and fat-containing foods are naturally susceptible to rapid rancification and other oxidative reactions that produce compounds having objectionable taste and odor, making foods containing them unpalatable. Lipid oxidation is autocatalytic and proceeds as a complex of chain reactions, the nature and speed of which vary with the substrate, temperature, light, availability of oxygen and presence or absence of oxidation catalysts. Antioxidants like BHT act as “chain breaks” in the autooxidation processes under the usual conditions of processing, storage and use of fat-containing foods (Burdock, 1997).
Not reported found naturally.
Because they prevent rancidity, antioxidants are of great interest to the food industry. For example, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and EDTA are frequently used to preserve various foods, such as cheese or fried products. Butylated hydroxytoluene is a powerful inhibitor of lipid peroxidation, yet large doses of it can induce oxidative DNA damage and cancer development in the rat forestomach.
BHT is also known as butylated hydroxy toluene. It is an anti-oxidant that also has preservative and masking capabilities.
Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.
Antioxidant 264 as general antioxidants is used widely in polymer materials, petroleum products and food processing industries. Antioxidant 264 is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm. This product does not change color, not pollution. Antioxidants 264 high solubility in oil, no precipitation, less volatile, non-toxic and non-corrosive.
Antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps. Antiskinning agent in paints and inks.
ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
BHT is produced commercially by the alkylation of para-cresol with isobutylene. BHT is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.
Vorbereitung Methode
Prepared by the reaction of p-cresol with isobutene.
Allgemeine Beschreibung
White crystalline solid.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.
2,6-Di-tert-butyl-4-methylphenol is combustible.
Pharmazeutische Anwendungen
Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.
This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.
Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
LD50 (guinea pig, oral): 10.7 g/kg
LD50 (mouse, IP): 0.14 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 0.65 g/kg
LD50 (rat, oral): 0.89 g/kg
mögliche Exposition
DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.
This radical scavenger and widely used antioxidant (FW = 220.36 g/mol; CAS 128-37-0; IUPAC Name: 2,6-bis(1,1-dimethylethyl)-4-methylphenol; Symbol: BHT; Soluble in most oils) inhibits food spoilage by terminating free radical reactions through the conversion of peroxy radicals (R–O2 ?) to hydroperoxides (R–OOH). This is accomplished by donating a hydrogen atom (Reaction: R–O2 ? + BHT–OH → ROOH + BHT–O?). where R is alkyl or aryl, and where BHT–OH indicates the hydroxyl group of butylated hydroxytoluene. The key to BHT’s effectiveness is the formation of a highly stabilized oxygen free radical that is poorly reactive due to steric contraints.
Erste Hilfe
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respira- tion with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with run- ning water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical obser- vation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized para- medic may consider administering a drug or other inhala- tion therapy.
Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
läuterung methode
Dissolve BHT in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]
Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.
Contact with oxidizers may cause fire and explosion hazard.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
2,6-Di-tert-butyl-p-kresol Upstream-Materialien And Downstream Produkte
Ethanol Isobutanol Orthophosphorsure 2-Methylpropanol-2 p-Kresol Natriumhydroxid
Downstream Produkte
2,6-Di-tert-butyl-p-kresol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 540)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Anhui Royal Chemical Co., Ltd.
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Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739 CHINA 558 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 China 19919 60
Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
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0086 158 5814 5714 (Mobile; WhatsApp; Telegram) CHINA 2672 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763 China 1752 55
Chemson Industrial (Shanghai) Co., Ltd.
86-21-65208861-ext8007 CHINA 117 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
128-37-0(2,6-Di-tert-butyl-p-kresol)Verwandte Suche:
Kalium-(E,E)-hexa-2,4-dienoat 2-Nitro-p-kresol N-ISOPROPYL-N-PHENYL-P-PHENYLENEDIAMINE 2,6-Di-tert-butyl-p-kresol 6,6'-Di-tert-butyl-4,4'-thiodi-m-kresol Poly(1,2-dihydro-2,2,4-trimethylquinoline) 2-tert-Butyl-p-kresol Pentaerythrittetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionat) Bromkresolgrün N,N'-Di-2-naphthyl-p-phenylendiamin 2,6-Dinitro-p-kresol 2-Mercaptobenzimidazol Kresol Buprofezin Antioxidant BLE 2,4-Di-tert-butylphenol O,O'-Dioctadecylpentaerythritbis(phosphit) 3-Ethylphenol
AntoxQT Antracine 8 Antrancine 8 antrancine8 antrancine8[qr] AO 29 AO 4K ao29 ao4k Bht(food grade) bht(foodgrade) Bis(1,1-dimethylethyl)-4-methylphenol BUKS Butylated hydroxytoluol ButylatedhydroxytoIuene ionolcp ionolcp[qr] Ionole kerabit Lowinox BHT Methyldi-tert-butylphenol NCI-C03598 Nipanox BHT Nipanox?BHT nocrac200 Nonox TBC nonoxtbc o,o’-di-tert-butyl-p-cresol o-Di-tert-butyl-p-methylphenol sumilizerbht Sustane BHT sustane[qr] sustanebht swanoxbht tenamen3 Tenamene 3 tenamene3 Tenox BHT tenoxbht Topanol vulkanoxkb VANLUBE(R) PCX AKOS BBS-00004321 BUTYLATED HYDROXYTOLUENE 99+% FCC BHT PG ButylBromideForSynthesis ButalatedHydroxyToluene(B.H.T.) Bht(Antioxidant) BUTYLATED HYDROXY TOLUENE (B.H.T.) (S)-3-(2-(5-bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran Butylated hydroxytoluene Manufacturer Butylated Hydroxytoluene 2,6-Di-tert-butyl-4-methylphenol di-tert-butylhydroxytoluene 2,6-DITERTIARY-BUTYL-4-METHYL-PHENOL(BHT) Butylated hydroxytoluene (BHT&2,6-DBPC) DI-TERT-BUTYL-PARA-CRESOL 2,6-DITERTIARYBUTYLPARACRESOL BHT (DI-TERT.-BUTYL-4-HYDROXYTOLUOL)
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