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2,6-Di-tert-butyl-p-kresol Produkt Beschreibung

Butylated Hydroxytoluene Struktur
128-37-0
CAS-Nr.
128-37-0
Bezeichnung:
2,6-Di-tert-butyl-p-kresol
Englisch Name:
Butylated Hydroxytoluene
Synonyma:
BHT;p21;ao4k;ao29;BUKS;SDI1;DBPC;E321;cao1;cao3
CBNumber:
CB8355755
Summenformel:
C15H24O
Molgewicht:
220.35
MOL-Datei:
128-37-0.mol

2,6-Di-tert-butyl-p-kresol Eigenschaften

Schmelzpunkt:
69-73 °C(lit.)
Siedepunkt:
265 °C(lit.)
Dichte
1.048
Dampfdichte
7.6 (vs air)
Dampfdruck
<0.01 mm Hg ( 20 °C)
FEMA 
2184 | BUTYLATED HYDROXYTOLUENE
Brechungsindex
1.4859
Flammpunkt:
127 °C
storage temp. 
0-6°C
Löslichkeit
methanol: 0.1 g/mL, clear, colorless
pka
pKa 14(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
Aggregatzustand
Crystals
Farbe
white
Geruch (Odor)
faint characteristic odor
Wasserlöslichkeit
insoluble
Merck 
14,1548
BRN 
1911640
Stabilität:
Stable, but light-sensitive. Incompatible with acid chlorides, acid anhydrides, brass, copper, copper alloys, steel, bases, oxidizing agents. Combustible.
InChIKey
NLZUEZXRPGMBCV-UHFFFAOYSA-N
CAS Datenbank
128-37-0(CAS DataBase Reference)
IARC
3 (Vol. 40, Sup 7) 1987
NIST chemische Informationen
Butylated hydroxytoluene(128-37-0)
EPA chemische Informationen
2,6-Di-tert-butyl-p-cresol (128-37-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,N
R-Sätze: 22-36/37/38-36/38-50/53
S-Sätze: 26-36-37/39-61-60
RIDADR  3077
WGK Germany  1
RTECS-Nr. GO7875000
8-10-23
Selbstentzündungstemperatur 878 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29071900
Giftige Stoffe Daten 128-37-0(Hazardous Substances Data)
Toxizität LD50 orally in mice: 1040 mg/kg (McOmie)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P272 Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

2,6-Di-tert-butyl-p-kresol Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE BIS BLASSGELBE KRISTALLE ODER PULVER.

CHEMISCHE GEFAHREN

Zersetzung beim Verbrennen und bei Kontakt mit oxidierenden Substanzen.

ARBEITSPLATZGRENZWERTE

TLV: (Einatembare Fraktion und Dampf) 2 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK: 20 mg/m?(Einatembare Fraktion) Spitzenbegrenzung: überschreitungsfaktor II(2); Krebserzeugend Kategorie 4; Schwangerschaft: Gruppe C; (DFG 2008).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.

INHALATIONSGEFAHREN

Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen und die Haut.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen. Möglich sind Auswirkungen auf die Leber.

LECKAGE

Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

The antioxidant butylated hydroxytoluene is contained in food, adhesive glues, industrial oils and greases, including cutting fluids. Sensitization seems very rare.

Chemische Eigenschaften

white crystalline solid

Chemische Eigenschaften

BHT is a white to pale yellow crystalline solid or powder.

Chemische Eigenschaften

Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.

Chemische Eigenschaften

BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. BHT has a very faint, musty, occasional cresylictype odor. BHA and BHT are extensively used in foods as antioxidants. Most fats, oils and fat-containing foods are naturally susceptible to rapid rancification and other oxidative reactions that produce compounds having objectionable taste and odor, making foods containing them unpalatable. Lipid oxidation is autocatalytic and proceeds as a complex of chain reactions, the nature and speed of which vary with the substrate, temperature, light, availability of oxygen and presence or absence of oxidation catalysts. Antioxidants like BHT act as “chain breaks” in the autooxidation processes under the usual conditions of processing, storage and use of fat-containing foods (Burdock, 1997).

Occurrence

Not reported found naturally.

Verwenden

Because they prevent rancidity, antioxidants are of great interest to the food industry. For example, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and EDTA are frequently used to preserve various foods, such as cheese or fried products. Butylated hydroxytoluene is a powerful inhibitor of lipid peroxidation, yet large doses of it can induce oxidative DNA damage and cancer development in the rat forestomach.

Verwenden

BHT is also known as butylated hydroxy toluene. It is an anti-oxidant that also has preservative and masking capabilities.

Verwenden

Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.

Verwenden

Antioxidant 264 as general antioxidants is used widely in polymer materials, petroleum products and food processing industries. Antioxidant 264 is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm. This product does not change color, not pollution. Antioxidants 264 high solubility in oil, no precipitation, less volatile, non-toxic and non-corrosive.

Verwenden

Antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps. Antiskinning agent in paints and inks.

Definition

ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.

synthetische

BHT is produced commercially by the alkylation of para-cresol with isobutylene. BHT is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.

Vorbereitung Methode

Prepared by the reaction of p-cresol with isobutene.

Allgemeine Beschreibung

White crystalline solid.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.

Health Hazard

2,6-Di-tert-butyl-p-cresol or BHT is of relatively low acute toxicity in animals, and there is no evidence of either acute or chronic effects among exposed workers.

Brandgefahr

2,6-Di-tert-butyl-4-methylphenol is combustible.

Pharmazeutische Anwendungen

Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.

Kontakt-Allergie

This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.

Carcinogenicity

The IARC has determined that there is limited evidence for the carcinogenicity of BHT in experimental animals.
BHT has given primarily negative results in a large number of in vivo and in vitro genotoxic assays.
No significant reproductive effects were observed in three-generation toxicity studies in mice administered up to 0.4% in the diet.6 The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for 2,6-ditert- butyl-p-cresol is 2mg/m3.

mögliche Exposition

DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.

Sicherheitsprofil

Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. A human skin irritant. A skin and eye irritant.Questionable carcinogen with experimental carcinogenicand.

Sicherheit(Safety)

Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
LD50 (guinea pig, oral): 10.7 g/kg
LD50 (mouse, IP): 0.14 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 0.65 g/kg
LD50 (rat, oral): 0.89 g/kg

Lager

Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

läuterung methode

Dissolve BHT in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]

Inkompatibilitäten

Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.

Inkompatibilitäten

Contact with oxidizers may cause fire and explosion hazard.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

2,6-Di-tert-butyl-p-kresol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2,6-Di-tert-butyl-p-kresol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 645)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Jiangxi alpha high tech Pharmaceutical Co., Ltd
86-51085010237
overseamarketing@alphahi-tech.com CHINA 41 58
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 602 58
RIANLON CORPORATION
+(86)13011086067 +86 18522174966
+86 22 8371 8815 market@rianlon.com CHINA 88 58
Ningxia Jinhua Chemical Co.,Ltd
025-52279164
025-52279193 info@nxjhchem.com CHINA 55 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22624 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3275 55
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 537 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55

128-37-0(2,6-Di-tert-butyl-p-kresol)Verwandte Suche:


  • AntoxQT
  • Antracine 8
  • Antrancine 8
  • antrancine8
  • antrancine8[qr]
  • AO 29
  • AO 4K
  • ao29
  • ao4k
  • Bht(food grade)
  • bht(foodgrade)
  • Bis(1,1-dimethylethyl)-4-methylphenol
  • BUKS
  • Butylated hydroxytoluol
  • ButylatedhydroxytoIuene
  • ionolcp
  • ionolcp[qr]
  • Ionole
  • kerabit
  • Lowinox BHT
  • Methyldi-tert-butylphenol
  • NCI-C03598
  • Nipanox BHT
  • Nipanox?BHT
  • nocrac200
  • Nonox TBC
  • nonoxtbc
  • o,o’-di-tert-butyl-p-cresol
  • o-Di-tert-butyl-p-methylphenol
  • sumilizerbht
  • Sustane BHT
  • sustane[qr]
  • sustanebht
  • swanoxbht
  • tenamen3
  • Tenamene 3
  • tenamene3
  • Tenox BHT
  • tenoxbht
  • Topanol
  • vulkanoxkb
  • dibutyi hydroxy toluene(BHT)
  • 2,6-Di-tert-butyl-4-methylphenol (2,6-Bis(1,1-dimethylethyl)-4-methylphenol)
  • Butylated hydroxytoluene,Granular
  • 264 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
  • 2,6-di-tert-butyl-4-methyphenol
  • 2,6-Di-tert-butyl-4-methylphenol ,98.5%
  • 2,6-Di-tert-butyl-4-methylphenol,2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, Butylhydroxytoluenum, DBPC
  • 2,6-Di-tert-butyl-4-methylphenol, synthesis grade
  • 2.6-Di-tert-butyl-p-cresol 5g [128-37-0]
  • 2.6-Di-tert-butyl-4-methylphenol 3g [128-37-0]
  • Butylated hydroxytoluene,2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC
  • Butylated Hydroxytoluene (500 mg)
  • Butylated Hydroxytoluene (500 mg) (AS)
  • VANLUBE(R) PCX
  • AKOS BBS-00004321
  • BUTYLATED HYDROXYTOLUENE 99+% FCC
  • BHT PG
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