Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

486460-00-8

CAS-Nr.: 486460-00-8

Englisch Name:: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Synonyma:: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid;(3R)-N-Boc-3-amin;BOC- Butanoic Acid;Parecoxib SodiuM API;BOC-(R)-3-AMINO-4-(2;Sitagliptin Impurity 78;Sitagliptin Impurity 19

CBNumber:: CB8402112

Summenformel:: C15H18F3NO4

Molgewicht:: 333.31

MOL-Datei:: 486460-00-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 393

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Eigenschaften

Schmelzpunkt:: 136-138℃

Siedepunkt:: 443.1±45.0 °C(Predicted)

Dichte: 1.292±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 4.30±0.10(Predicted)

Farbe: White to Off-White

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

HazardClass	IRRITANT

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P

Sicherheit

P305+P351+P338

BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.

Verwenden

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.

Synthese

(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Sitagliptin N-Boc IMpurity

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 393)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Allfluoro pharmaceutical co. ltd.	021-26137118 +8615821363818	sales@allfluoro.com	China	5791	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	811	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55

486460-00-8()Verwandte Suche:

Sebacinsure Butyraldehyd Ethylenoxid 1-Hydroxybenzotriazol N'-(Ethylkohlenstoffimidoyl)-N,N-dimethylpropan-1,3-diaminhydrochlorid Natrium octadecylfumarat 2,2-Dimethyl-1,3-dioxan-4,6-dion 1,1-Dichlorethen 2,4-Difluorphenylessigsure Ethyltrifluoracetat 3,4-Difluorphenylessigsure

Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-
(R)-Sitagliptin N-Boc-Acid IMpurity
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%
(3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
(3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl) butanoic acid (BOC acid)
[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID
(R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid
Sitagliptin Intermediate 1
[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid
(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU
3(R)-tert-ButoxycarbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid
(3R)-3-(1,1-Dimethylethoxy carbonyl) amino]- 4-(2,4,5-trifluorophenyl) butanoic acid
Sitagliptin interMediate
(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic
(3R)-3-((1,1-DIMETHYLETHOXYCARBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID
(R)-3-(Boc-aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
4-(6-{[(tert-butoxy)carbonyl]aMino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid
Parecoxib SodiuM API
Sitagliptin interMediateB
(3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
Sitagliptin impurity 19/(R)-Sitagliptin N-Boc-Acid Impurity/(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)
Sitagliptin Acid Boc Impurity (Impurity A)
BOC- Butanoic Acid
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY
Sitagliptin Impurity 78
Sitagliptin N-BOC Carboxylic acid Impurity
(Tert-Butoxy)Carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid
Sitagliptin Impurity 19
(3R)-N-Boc-3-amin
(3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]
Sitagliptin N-BOC Carboxylic Acid
Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci
SITAGLIPTIN CAS 654671-78-0 INTERMEDIATES
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH
Sitagliptin EP Impurity 15
5-TRIFLUORO-PHENYL)-BUTYRIC ACID
BOC-(R)-3-AMINO-4-(2
N-Boc Sitagliptin Acid Impurity
Sitagliptin Imp-1(sitagliptin Impurity-A)
[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be...
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid
Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate
(βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid)
Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
(3R) - N - (tert butoxycarbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid
BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid
Sitagliptin Impurity 19 (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid
Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid
486460-00-8