Benzhydrylalkohol
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- CAS-Nr.
- 91-01-0
- Bezeichnung:
- Benzhydrylalkohol
- Englisch Name:
- Benzhydrol
- Synonyma:
- DIPHENYLMETHANOL;benzydrol;Benzhydryl alcohol;BENZOHYDROL;DIPHENYLCARBINOL;ALPHA-PHENYLBENZENEMETHANOL;NSC 32150;BENZHYDROL;BNEZHYDROL;Benzhydrol >
- CBNumber:
- CB8417044
- Summenformel:
- C13H12O
- Molgewicht:
- 184.24
- MOL-Datei:
- 91-01-0.mol
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Benzhydrylalkohol Eigenschaften
- Schmelzpunkt:
- 65-67 °C (lit.)
- Siedepunkt:
- 297-298 °C (lit.)
- Dichte
- 1.0120 (rough estimate)
- Dampfdruck
- 0.000076 hPa (20 °C)
- Brechungsindex
- 1.5727 (estimate)
- Flammpunkt:
- 160 °C
- storage temp.
- Store below +30°C.
- Löslichkeit
- 0.52g/l insoluble
- Aggregatzustand
- Crystalline Solid
- pka
- 13.55±0.20(Predicted)
- Farbe
- White to beige
- Geruch (Odor)
- at 100.00 %. weedy green rose
- Geruchsart
- green
- Wasserlöslichkeit
- Slightly soluble in water.
- Merck
- 14,1090
- BRN
- 1424379
- Stabilität:
- Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.
- LogP
- 2.670
- CAS Datenbank
- 91-01-0(CAS DataBase Reference)
- NIST chemische Informationen
- Benzenemethanol, «alpha»-phenyl-(91-01-0)
- EPA chemische Informationen
- Benzenemethanol, .alpha.-phenyl- (91-01-0)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher |
Xi |
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R-Sätze: |
36/37/38 |
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S-Sätze: |
26-36-24/25 |
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WGK Germany |
2 |
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RTECS-Nr. |
DC7452000 |
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Hazard Note |
Irritant |
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TSCA |
Yes |
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HS Code |
29062900 |
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Toxizität |
LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H303 |
May be harmfulif swallowed |
Acute toxicity,oral |
Category 5 |
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P312 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
H320 |
Causes eye irritation |
Serious eye damage/eye irritation |
Category 2B |
Warnung |
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P264, P305+P351+P338,P337+P313 |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
P405 |
Unter Verschluss aufbewahren. |
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Benzhydrylalkohol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
off-white powder
Verwenden
- Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
- Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
- Intermediate in the preparation of Modafinil (M482500).
Reaktionen
Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.
Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.
Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
läuterung methode
Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]
Benzhydrylalkohol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Benzhydrylalkohol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 586)Lieferanten
Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
TAIZHOU DKD CHEMICAL CO., LTD.
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+8618658336633
|
yf.chen@tzdkdchem.com |
China |
134 |
58 |
Hebei Mojin Biotechnology Co., Ltd
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+8613288715578
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sales@hbmojin.com |
China |
12452 |
58 |
Capot Chemical Co.,Ltd.
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571-85586718 +8613336195806
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sales@capotchem.com |
China |
29797 |
60 |
Shanghai Daken Advanced Materials Co.,Ltd
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+86-371-66670886
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info@dakenam.com |
China |
14936 |
58 |
Henan Tianfu Chemical Co.,Ltd.
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+86-0371-55170693 +86-19937530512
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info@tianfuchem.com |
China |
21700 |
55 |
Hangzhou FandaChem Co.,Ltd.
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008657128800458; +8615858145714
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fandachem@gmail.com |
China |
9354 |
55 |
Jiangsu Qingquan Chemical Co., Ltd.
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+86-571-86589381,86589382,86589383
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sales1@qqpharm.com |
CHINA |
154 |
55 |
Hefei TNJ Chemical Industry Co.,Ltd.
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+86-0551-65418679 +86-18949832763
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info@tnjchem.com |
China |
2989 |
55 |
Shanxi Naipu Import and Export Co.,Ltd
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+86-13734021967 +8613734021967
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kaia@neputrading.com |
China |
1011 |
58 |
career henan chemical co
|
+86-0371-86658258
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sales@coreychem.com |
China |
29914 |
58 |
91-01-0(Benzhydrylalkohol)Verwandte Suche:
Benzylalkohol
Diphenylsilandiol
4'-tert-Butyl-4-chlorbutyrophenon
p-tert-Butylacetophenon
3',6'-Dihydroxy-2',4',5',7'-tetraiodspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-on
4,4'-Difluorbenzhydrylalkohol
4',5'-Dibrom-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-on
Benzilsure
Methylbenzilat
4,4'-dichlor-α-phenylbenzylalkohol
2-(2,7-Dichlor-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoesure
4-Hydroxy-α-(4-hydroxynaphthyl)-α-phenylnaphthalin-1-methanol
α-o-Tolylbenzylalkohol
3,3-Bis(4-hydroxy-3,5-diiodphenyl)phthalid
Dibenzo[b,f]cyclohepten-1-ol
4-Chlorbenzhydrylalkohol
Triphenylmethanol
α-p-Tolylbenzylalkohol
- BENZHYDROL
- HYDROXYDIPHENYL METHANE
- Benzenemethanol,alpha-phenyl-
- alpha-phenyl-benzenemethano
- a-Phenylbenzenemethanol
- a-Phenylbenzyl alcohol
- DIPHENYLCARBINOL(BENZHYDROL)
- PARA-HYDROXYDIPHENYLMETHANE
- Benzhydrylalkohol
- BNEZHYDROL
- DIPHENYCARBINOL pure
- Benzhydryl alcoho
- Diphenylmethanol,Benzhydrol, Diphenyl carbinol
- NSC 32150
- α-Phenylbenzyl Alcohol
- Diphenylcarbinol
Diphenylmethanol
- BENZHYDROL FOR SYNTHESIS 250 G
- BENZHYDROL FOR SYNTHESIS 1 KG
- Benzhydrol, 99% 100GR
- Twophenyl carbinol
- Benzhydrol (50 mg)
- Diphenylmethanol, >=99%
- DiphenylMethanol 99%
- Benzhydrol for synthesis
- Benzhydrol,(Diphenylcarbinol
- Trichlorethyl Benzoquinone
- BENZHYDROL 99%
- BENZHYDROL 99+%
- benzhydrylalcohol
- Diphenylmethyl alcohol
- diphenylmethylalcohol
- α-phenylbenzenemethanol
- Diphenhydramine EP impurity D
- Ebastine Impurity 1(EP Impurity A)
- 4-Methyl-&alpha
- Dimenhydrinate EP Impurity I
- diphenyl-(2-pyridin-4-ylcyclopropyl)methanol
- 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-&alpha
- Dimenhydrinate EP Impurity D(Benzyhydrol)
- Diphenhydramine Impurity 4(Diphenhydramine EP Impurity D)
- Benzhydrol >
- Cyclizine impurity B CRS
- Benzenemethanol, α-phenyl-
- Dimenhydrinate EP Impurity I (Benzhydrol)
- Dimenhydrinate Impurity 9 (Dimenhydrinate EP Impurity I)
- Diphenhydramine EP Impurity D (Diphenylmethanol/ Benzhydrol)
- Diphenylcarbinol pure, 99%
- Cyclizine impurity B (Y0000887)
- Diphenhydramine Impurity D
- ALPHA-PHENYLBENZENEMETHANOL
- BENZOHYDROL
- DIPHENYLCARBINOL
- DIPHENYLMETHANOL
- Benzhydryl alcohol
- benzydrol
- Diphenhydramine EP Impurity D(Dimenhydrinate EP Impurity I/Ebastine EP Impurity A)
- Diphenhydramine Hydrochloride EP Impurity D
- Dimenhydrinate EP Impurity I (Cyclizine EP Impurity B, Diphenhydramine EP Impurity D, Ebastine EP Impurity A, Benzhydrol)