Benzhydrylalkohol

Benzhydrol Struktur
91-01-0
CAS-Nr.
91-01-0
Bezeichnung:
Benzhydrylalkohol
Englisch Name:
Benzhydrol
Synonyma:
DIPHENYLMETHANOL;benzydrol;Benzhydryl alcohol;BENZOHYDROL;DIPHENYLCARBINOL;ALPHA-PHENYLBENZENEMETHANOL;NSC 32150;BENZHYDROL;BNEZHYDROL;Benzhydrol >
CBNumber:
CB8417044
Summenformel:
C13H12O
Molgewicht:
184.24
MOL-Datei:
91-01-0.mol

Benzhydrylalkohol Eigenschaften

Schmelzpunkt:
65-67 °C (lit.)
Siedepunkt:
297-298 °C (lit.)
Dichte
1.0120 (rough estimate)
Dampfdruck
0.000076 hPa (20 °C)
Brechungsindex
1.5727 (estimate)
Flammpunkt:
160 °C
storage temp. 
Store below +30°C.
Löslichkeit
0.52g/l insoluble
Aggregatzustand
Crystalline Solid
pka
13.55±0.20(Predicted)
Farbe
White to beige
Geruch (Odor)
at 100.00 %. weedy green rose
Geruchsart
green
Wasserlöslichkeit
Slightly soluble in water.
Merck 
14,1090
BRN 
1424379
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.
LogP
2.670
CAS Datenbank
91-01-0(CAS DataBase Reference)
NIST chemische Informationen
Benzenemethanol, «alpha»-phenyl-(91-01-0)
EPA chemische Informationen
Benzenemethanol, .alpha.-phenyl- (91-01-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36-24/25
WGK Germany  2
RTECS-Nr. DC7452000
Hazard Note  Irritant
TSCA  Yes
HS Code  29062900
Toxizität LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warnung P264, P305+P351+P338,P337+P313
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Benzhydrylalkohol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

off-white powder

Verwenden

  1. Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
  2. Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
  3. Intermediate in the preparation of Modafinil (M482500).

Reaktionen

Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.
Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.
Reduction of benzophenone to benzhydrol
Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

läuterung methode

Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]

Benzhydrylalkohol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Benzhydrylalkohol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 586)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
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91-01-0(Benzhydrylalkohol)Verwandte Suche:


  • BENZHYDROL
  • HYDROXYDIPHENYL METHANE
  • Benzenemethanol,alpha-phenyl-
  • alpha-phenyl-benzenemethano
  • a-Phenylbenzenemethanol
  • a-Phenylbenzyl alcohol
  • DIPHENYLCARBINOL(BENZHYDROL)
  • PARA-HYDROXYDIPHENYLMETHANE
  • Benzhydrylalkohol
  • BNEZHYDROL
  • DIPHENYCARBINOL pure
  • Benzhydryl alcoho
  • Diphenylmethanol,Benzhydrol, Diphenyl carbinol
  • NSC 32150
  • α-Phenylbenzyl Alcohol
  • Diphenylcarbinol Diphenylmethanol
  • BENZHYDROL FOR SYNTHESIS 250 G
  • BENZHYDROL FOR SYNTHESIS 1 KG
  • Benzhydrol, 99% 100GR
  • Twophenyl carbinol
  • Benzhydrol (50 mg)
  • Diphenylmethanol, >=99%
  • DiphenylMethanol 99%
  • Benzhydrol for synthesis
  • Benzhydrol,(Diphenylcarbinol
  • Trichlorethyl Benzoquinone
  • BENZHYDROL 99%
  • BENZHYDROL 99+%
  • benzhydrylalcohol
  • Diphenylmethyl alcohol
  • diphenylmethylalcohol
  • α-phenylbenzenemethanol
  • Diphenhydramine EP impurity D
  • Ebastine Impurity 1(EP Impurity A)
  • 4-Methyl-&alpha
  • Dimenhydrinate EP Impurity I
  • diphenyl-(2-pyridin-4-ylcyclopropyl)methanol
  • 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-&alpha
  • Dimenhydrinate EP Impurity D(Benzyhydrol)
  • Diphenhydramine Impurity 4(Diphenhydramine EP Impurity D)
  • Benzhydrol >
  • Cyclizine impurity B CRS
  • Benzenemethanol, α-phenyl-
  • Dimenhydrinate EP Impurity I (Benzhydrol)
  • Dimenhydrinate Impurity 9 (Dimenhydrinate EP Impurity I)
  • Diphenhydramine EP Impurity D (Diphenylmethanol/ Benzhydrol)
  • Diphenylcarbinol pure, 99%
  • Cyclizine impurity B (Y0000887)
  • Diphenhydramine Impurity D
  • ALPHA-PHENYLBENZENEMETHANOL
  • BENZOHYDROL
  • DIPHENYLCARBINOL
  • DIPHENYLMETHANOL
  • Benzhydryl alcohol
  • benzydrol
  • Diphenhydramine EP Impurity D(Dimenhydrinate EP Impurity I/Ebastine EP Impurity A)
  • Diphenhydramine Hydrochloride EP Impurity D
  • Dimenhydrinate EP Impurity I (Cyclizine EP Impurity B, Diphenhydramine EP Impurity D, Ebastine EP Impurity A, Benzhydrol)
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