InSolution Rapamycin - Calbiochem

InSolution Rapamycin - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC₅₀ = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.

Biochem/physiol Actions

Primary TargetMammalian target of rapamycin (mTOR)

InSolution Rapamycin - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

InSolution Rapamycin - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

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• InSolution Rapamycin - Calbiochem