DMT-2′Fluoro-dU Phosphoramidite Chemische Eigenschaften,Einsatz,Produktion Methoden
Definition
DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA
DMT-2′Fluoro-dU Phosphoramidite Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte