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Chlorbutanol Produkt Beschreibung

Chlorobutanol Struktur
57-15-8
CAS-Nr.
57-15-8
Bezeichnung:
Chlorbutanol
Englisch Name:
Chlorobutanol
Synonyma:
HCP;HRC;HCPH;PTN6;PTPN6;PTP-1C;SHP-1L;HPTP1C;70Z-SHP;SH-PTP1
CBNumber:
CB8715683
Summenformel:
C4H9ClO
Molgewicht:
108.57
MOL-Datei:
57-15-8.mol

Chlorbutanol Eigenschaften

Schmelzpunkt:
~78 °C
Siedepunkt:
173 °C
Dichte
1.3170 (estimate)
Flammpunkt:
>110°C
storage temp. 
-20°C
Löslichkeit
Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
Stabilität:
Stable. Generates toxic fumes on combustion.
CAS Datenbank
57-15-8(CAS DataBase Reference)
NIST chemische Informationen
2-(Trichloromethyl)-2-propanol(57-15-8)
EPA chemische Informationen
2-Propanol, 1,1,1-trichloro-2-methyl-(57-15-8)

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/37/38
S-Sätze: 26-36/37/39
WGK Germany  3
Giftige Stoffe Daten 57-15-8(Hazardous Substances Data)
Toxizität MLD orally in dogs, rabbits (mg/kg): 238, 213 (Impens)

Chlorbutanol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

Volatile, colorless or white crystals with a musty, camphoraceous odor.

Chemische Eigenschaften

White or almost white, crystalline powder or colourless crystals, sublimes readily

Verwenden

Plasticizer for cellulose esters and ethers, preservative for biological fluids and solutions, antimicrobial agent, anesthetic in dentistry.

Vorbereitung Methode

Chlorobutanol is prepared by condensing acetone and chloroform in the presence of solid potassium hydroxide.

Hazard

Action similar to chloral hydrate. Combustible.

Pharmazeutische Anwendungen

Chlorobutanol is primarily used in ophthalmic or parenteral dosage forms as an antimicrobial preservative at concentrations up to 0.5% w/v. It is commonly used as an antibacterial agent for epinephrine solutions, posterior pituitary extract solutions, and ophthalmic preparations intended for the treatment of miosis. It is especially useful as an antibacterial agent in nonaqueous formulations. Chlorobutanol is also used as a preservative in cosmetics ; as a plasticizer for cellulose esters and ethers; and has been used therapeutically as a mild sedative and local analgesic in dentistry.

Sicherheitsprofil

Poison by ingestion. A narcotic. A skin and eye irritant. Mutation data reported. See also CHLORAL HYDRATE, whch acts similarly. Dangerous; can react with oxidizing materials. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also PHOSGENE.

Sicherheit(Safety)

Chlorobutanol is widely used as a preservative in a number of pharmaceutical formulations, particularly ophthalmic preparations. Although animal studies have suggested that chlorobutanol may be harmful to the eye, in practice the widespread use of chlorobutanol as a preservative in ophthalmic preparations has been associated with few reports of adverse reactions. A study of the irritation potential of a local anesthetic on the murine cornea indicated significant corneal surface damage in the presence of 0.5% w/v chlorobutanol, which may be related to the preservative’s effective concentration. Reported adverse reactions to chlorobutanol include: cardiovascular effects following intravenous administration of heparin sodium injection preserved with chlorobutanol; neurological effects following administration of a large dose of morphine infusion preserved with chlorobutanol; and hypersensitivity reactions, although these are regarded as rare.
The lethal human dose of chlorobutanol is estimated to be 50–500 mg/kg.
LD50 (dog, oral): 0.24 g/kg
LD50 (mouse, oral): 0.99 g/kg
LD50 (rabbit, oral): 0.21 g/kg

Lager

Chlorobutanol is volatile and readily sublimes. In aqueous solution, degradation to carbon monoxide, acetone and chloride ion is catalyzed by hydroxide ions. Stability is good at pH 3 but becomes progressively worse with increasing pH. The half-life at pH 7.5 for a chlorobutanol solution stored at 258℃ was determined to be approximately 3 months. In a 0.5% w/v aqueous chlorobutanol solution at room temperature, chlorobutanol is almost saturated and may crystallize out of solution if the temperature is reduced.
Losses of chlorobutanol also occur owing to its volatility, with appreciable amounts being lost during autoclaving; at pH 5 about 30% of chlorobutanol is lost. Porous containers result in losses from solutions, and polyethylene containers result in rapid loss. Losses of chlorobutanol during autoclaving in polyethylene containers may be reduced by pre-autoclaving the containers in a solution of chlorobutanol; the containers should then be used immediately. There is also appreciable loss of chlorobutanol through stoppers in parenteral vials.
The bulk material should be stored in an airtight container at a temperature of 8–158℃.

Inkompatibilitäten

Owing to problems associated with sorption, chlorobutanol is incompatible with plastic vials, rubber stoppers, bentonite, magnesium trisilicate, polyethylene, and polyhydroxyethylmethacrylate, which has been used in soft contact lenses. To a lesser extent, carboxymethylcellulose and polysorbate 80 reduce antimicrobial activity by sorption or complex formation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM, IV, and SC injection; inhalations; nasal, otic, ophthalmic, and topical preparations). Labeling must state ‘contains chlorobutanol up to 0.5%.’ Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
In the UK, the maximum concentration of chlorobutanol permitted for use in cosmetics, other than foams, is 0.5%. It is not suitable for use in aerosols.

Chlorbutanol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlorbutanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 130)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21707 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2997 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58

57-15-8(Chlorbutanol)Verwandte Suche:


  • hlorobutanol
  • ,,-Trichloro-tert-butylalcohol
  • .beta.,.beta.,.beta.,-Trichloro-tert.-butanol
  • 1,1,1-trichloro-2-methyl-2-propano
  • 1,1,1-Trichloro-tert-butyl alcohol
  • 1,1,1-trichloro-tert-butylalcohol
  • 2-(Trichloromethyl)propan-2-ol
  • 2,2,2-Trichloro-1,1-dimethylethanol
  • 2-methyl-1,1,1-trichloro-2-propano
  • 2-Propanol, 1,1,1-trichloro-2-methyl-
  • 2-Propanol, 2-methyl-1,1,1-trichloro-
  • Acetochlorone
  • Acetonchloroform
  • anhydrouschlorobutanol
  • Chlorbutanol
  • Chloreton
  • chlorobutanol,anhydrous
  • Chlortran
  • Clortran
  • Coliquifilm
  • Dentalone
  • HCP
  • Khloreton
  • Methaform
  • Sedaform
  • tert-Trichlorobutyl alcohol
  • Trichlorobutanol
  • Trichloro-t-butyl alcohol
  • trichloro-t-butylalcohol
  • Trichloro-tert-butyl alcohol
  • trichloro-tert-butylalcohol
  • t-Trichlorobutyl alcohol
  • t-trichlorobutylalcohol
  • β,β,β-Trichloro-tert-butano
  • PTP-1C
  • PTPN6
  • SHP-1 Active human
  • SHP-1L
  • ANTI-HRC (CENTER) antibody produced in rabbit
  • HRC
  • Sarcoplasmic reticulum histidine-rich calcium-binding protein
  • 70Z-SHP
  • Anti-SHP-1, C-Terminal antibody produced in rabbit
  • HCPH
  • Hematopoietic cell protein-tyrosine phosphatase
  • PTN6
  • CHLORETONE
  • BETA,BETA,BETA-TRICHLORO-TERT-BUTYL ALCOHOL
  • 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL
  • 2-TRICHLOROMETHYL-2-PROPANOL
  • 2-METHYL-1,1,1-TRICHLORO-2-PROPANOL
  • ACETONE CHLOROFORM
  • 2-Trichhloromethyl-2-propanol
  • Acetone chloroform~Chloretone~Chlorobutanol~1-Methyl-1-(trichloromethyl)ethanol~1,1,1-Trichloro-2-methyl-2-propanol
  • ACETONE CHLOROFORM HEMIHYDRATE DAB, PH. EUR., B.P., N. F., PH. FRANC.
  • CHLORBUTOLANHYDROUS
  • CHLOROBUTANOL,ANHYDROUS,NF
  • β, β, β-Trichloro-tert-butanol hemihydrate
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