Anagrelide hydrochloride
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- CAS-Nr.
- 58579-51-4
- Englisch Name:
- Anagrelide hydrochloride
- Synonyma:
- ANAGRELIDE HCL;AGRYLIN;RL 603;Xagrid;Agrelin;BL-4162A;Agryline,HCl;BMY-26538-01;TroMboreductin;Xagrid hydrochloride
- CBNumber:
- CB8722913
- Summenformel:
- C10H8Cl3N3O
- Molgewicht:
- 292.55
- MOL-Datei:
- 58579-51-4.mol
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Anagrelide hydrochloride Eigenschaften
- Schmelzpunkt:
- >280°C
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble1mg/mL, clear (warmed)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- CAS Datenbank
- 58579-51-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22-36/37/38 |
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| S-Sätze: |
26 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Anagrelide hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.
Chemische Eigenschaften
Off-White Powder
Definition
ChEBI: The hydrochloride salt of anagrelide.
Allgemeine Beschreibung
Anagrelide belongs to the imidazo[2,1-
b]quinazolin-2-one series of compounds.
Biologische Aktivität
Potent type III phosphodiesterase (PDE3) inhibitor (IC 50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.
Anagrelide hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Anagrelide hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 190)Lieferanten
58579-51-4()Verwandte Suche:
- 1-b)quinazolin-2(3h)-one,6,7-dichloro-1,5-dihydro-imidazo(monohydrochlorid
- 6,7-DICHLORO-1,5-DIHYDROIMIDAZO[2,1-B]QUINAZOLIN-2(3H)-ONE MONOHYDROCHLORIDE
- ANAGRELIDE HYDROCHLORIDE
- BL-4162A
- BMY-26538-01
- AnagrelideHclC10H7C12N30.HC1
- Agryline,HCl
- BL-4162A, BMY-26538-01, Agrylin,
- 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-onehydrochloride
- RL 603
- TroMboreductin
- Xagrid
- Anagrelide hydrochloride(BL 4162A)
- 6,7-Dichloro-5,10-dihydroiMidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
- 6,7-dichloroimidazo[2,1-b]quinazolin-2(1H,3H,5H)-one hydrochloride
- Anagrelide hydrochloride, >=99%
- Agrylin hydrochloride
- AGRYLIN HYDROCHLORIDE;XAGRID HYDROCHLORIDE;BL4162A
- Xagrid hydrochloride
- Anagrelide hydrochloride USP/EP/BP
- Anagrelide HydrochlorideQ: What is
Anagrelide Hydrochloride Q: What is the CAS Number of
Anagrelide Hydrochloride Q: What is the storage condition of
Anagrelide Hydrochloride Q: What are the applications of
Anagrelide Hydrochloride
- AGRYLIN
- ANAGRELIDE HCL
- Agrelin
- 58579-51-4
- 5879-51-4
- C10H7Cl2N3OClH
- C10H7Cl2N3OClHH2O
- C10H8Cl3N3O
- C10H7Cl2N3OHCl
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