(3β,4α)-3,23-Dihydroxyolean-12-en-28-sure
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- CAS-Nr.
- 465-99-6
- Bezeichnung:
- (3β,4α)-3,23-Dihydroxyolean-12-en-28-sure
- Englisch Name:
- Hederagenin
- Synonyma:
- Hederidin;NSC 24954;HEDERAGENIN;hederagenol;Hederogenin;Rangefinder;Hederagenine;MELANTHIGENIN;Vaccaric acid;Kalosapogenin
- CBNumber:
- CB8739586
- Summenformel:
- C30H48O4
- Molgewicht:
- 472.71
- MOL-Datei:
- 465-99-6.mol
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(3β,4α)-3,23-Dihydroxyolean-12-en-28-sure Eigenschaften
- Schmelzpunkt:
- 332-334°
- alpha
- D20 +81° (c = 0.7 in pyridine)
- Siedepunkt:
- 493.44°C (rough estimate)
- Dichte
- 0.9871 (rough estimate)
- Brechungsindex
- 1.4800 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- methanol: soluble1mg/mL
- pka
- 4.63±0.70(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- maximale Wellenlänge (λmax)
- 405nm(H2SO4)(lit.)
- Merck
- 14,4624
- InChIKey
- PGOYMURMZNDHNS-MYPRUECHSA-N
- LogP
- 7.410 (est)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
22 |
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| S-Sätze: |
22-45-24/25 |
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| WGK Germany |
3 |
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| HS Code |
29181990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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(3β,4α)-3,23-Dihydroxyolean-12-en-28-sure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Hederagenin is a triterpene saponin that has been found in
P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells.
In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemische Eigenschaften
White Solid
Verwenden
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
(3β,4α)-3,23-Dihydroxyolean-12-en-28-sure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(3β,4α)-3,23-Dihydroxyolean-12-en-28-sure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 248)Lieferanten
465-99-6((3β,4α)-3,23-Dihydroxyolean-12-en-28-sure)Verwandte Suche:
(20R,25R)-Spirost-5-en-3β-ol
ACETIC ACID
Folsure
Ginsenoside Rh2
4-Hydroxyzimtsure
3β-Hydroxyolean-12-en-28-sure
ASCORBICACID
Escin sodium
(3β,4α,16α)-3,16,23-Trihydroxyolean-12-en-28-sure
Ginsenosides
Olean-12-en-28-olsure, 3-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, O-6-Deoxy-α-L-mannopyranosyl-(1-4)-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranosylester, (3β,4α)-
(4α)-3β-[[2-O-(6-Desoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-sure
(3β,4α)-3,23-Dihydroxyolean-12-en-28-sure
- 3,23-Dihydroxyolean-12-en-28-acid
- Hederagenin, >=98%
- HEDERAGENIN(RG)
- (3β,4α) -3,23-Dihydroxy-olean-12-en- 28-oic acid
- CAULOSAPOGENIN
- HEDERAGENIN
- 3,23-DIHYDROXYOLEAN-12-EN-28 OIC ACID
- (3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid
- 3,23-dihydroxy-,(3-beta,4-alpha)-olean-12-en-28-oicaci
- 3-beta,23-dihydroxy-olean-12-en-28-oicaci
- astrantiagenine
- hederagenicacid
- hederagenol
- MELANTHIGENIN
- CAULOSAPOGENIN hplc
- HEDERAGENIN WITH HPLC
- (3b,4a)-3,23-Dihydroxyolean-12-en-28-oic acid
- (4R)-3β,23-Dihydroxyolean-12-en-28-oic acid
- Hederogenin
- Vaccaric acid
- (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-methylol-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
- (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
- Hederidin
- Kalosapogenin
- Hederagenine
- NSC 24954
- Olean-12-en-28-oicacid, 3,23-dihydroxy-, (3b,4a)-
- (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylicaci
- Rangefinder
- Hederagenin 465-99-6
- Hederagenin, 98%, from Hedera nepalensisvar.sinensis
- (4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-Hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
- Olean-12-en-28-oic acid, 3,23-dihydroxy-, (3β,4α)-
- 465-99-6
- 14126-03-6
- Saponins
- Pentacyclic Triterpenes
- Inhibitors
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Detergent
- Intermediates & Fine Chemicals
- Pharmaceuticals
