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L-Leucin Produkt Beschreibung

L-Leucine Struktur
61-90-5
CAS-Nr.
61-90-5
Bezeichnung:
L-Leucin
Englisch Name:
L-Leucine
Synonyma:
LEU;L-LEU;Leucin;LEUCINE;CH79091;H-LEU-OH;L-Leu-OH;1-Leucine;L-LEUCINE;FEMA 3297
CBNumber:
CB8742186
Summenformel:
C6H13NO2
Molgewicht:
131.17
MOL-Datei:
61-90-5.mol

L-Leucin Eigenschaften

Schmelzpunkt:
>300 °C(lit.)
alpha 
15.4 º (c=4, 6N HCl)
Dichte
1,293 g/cm3
Dampfdruck
<1 hPa (20 °C)
Brechungsindex
1.4630 (estimate)
FEMA 
3297 | L-LEUCINE
Flammpunkt:
145-148°C
storage temp. 
Store at RT.
Löslichkeit
1 M HCl: 50 mg/mL
Aggregatzustand
powder
pka
2.328(at 25℃)
Farbe
White to Off-white
PH
5.5-6.5 (20g/l, H2O, 20℃)
Optische Aktivität
[α]20/D +15.5°, c = 2 in 6 M HCl
Wasserlöslichkeit
22.4 g/L (20 C)
maximale Wellenlänge (λmax)
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number
1423
Sublimation 
145-148 ºC
Merck 
14,5451
BRN 
1721722
Stabilität:
Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
CAS Datenbank
61-90-5(CAS DataBase Reference)
NIST chemische Informationen
Leucine(61-90-5)
EPA chemische Informationen
L-Leucine(61-90-5)

Sicherheit

S-Sätze: 24/25
WGK Germany  3
RTECS-Nr. OH2850000
TSCA  Yes
HS Code  29224995

L-Leucin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Small, white, lustrous plates, or a white, crystalline powder, with a slightly bitter taste. One g dissolves in about 40 mL of water and in about 100 mL of acetic acid. It is sparingly soluble in alcohol, but is soluble in dilute hydrochloric acid and in solutions of alkali hydroxides and carbonates. ι-Leucine may be synthesized by bromination, followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.

Chemische Eigenschaften

L-Leucine is odorless and has a slightly bitter taste. L-Leucine is a branched-chain, essential amino acid that stimulates muscle protein synthesis.

Chemische Eigenschaften

White crystalline powder

Chemische Eigenschaften

Leucine occurs as a white or almost off-white crystalline powder or shiny flakes.

Occurrence

Reported found as a constituent in proteins; also present in the free state in the human body

Verwenden

Amino acid.

Definition

ChEBI: The L-enantiomer of leucine.

synthetische

By bromination followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.

Vorbereitung Methode

Leucine is produced microbially by incubating an amino-acidproducing microorganism including but not exclusive to Pseudomonas, Escherichia, Bacillus, or Staphylococcus in the presence of oxygen and a hydrocarbon. The nutrient medium should contain an inhibitory amount of a growth inhibitor that is a chemically similar derivative of leucine (e.g. methylallylglycine, a-hydrozinoisocaproic acid, or b-cyclopentanealanine) to inhibit the growth of the organism except for at least one mutant that is resistant to the inhibitory effect. The resistant mutant is then isolated and grown in the presence of oxygen and the hydrocarbon in the absence of the inhibitor. The mutant cells are then harvested and a nutrient medium is formed that includes a hydrocarbon as the sole source of carbon. Finally, the harvested cells are incubated in the medium in the presence of oxygen.

Pharmazeutische Anwendungen

Leucine is used in pharmaceutical formulations as a flavoring agent. It has been used experimentally as an antiadherent to improve the deagglomeration of disodium cromoglycate micro-particles and other compounds in inhalation preparations; and as a tablet lubricant. Leucine copolymers have been shown to successfully produce stable drug nanocrystals in water.

Sicherheit(Safety)

Leucine is an essential amino acid and is consumed as part of a normal diet. It is generally regarded as a nontoxic and nonirritant material. It is moderately toxic by the subcutaneous route.
LD50 (rat, IP): 5.379 g/kg

Lager

Leucine is sensitive to light and moisture, and should be stored in an airtight container in a cool, dark, dry place.

läuterung methode

Likely impurities are isoleucine, valine, and methionine. Crystallise L-leucine from water by adding 4 volumes of EtOH. It sublimes at 180-188o/0.3mm with 99.1% recovery, and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2075-2094 1961, Kameda et al. J Pharm Soc Jpn 78 763 1958, Beilstein 4 IV 2738.]

Inkompatibilitäten

Leucine is incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV infusion; oral tablets). Included in nonparenteral medicines licensed in the UK.

L-Leucin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


L-Leucin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 513)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21956 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 3911 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58

61-90-5(L-Leucin)Verwandte Suche:


  • (s)-2-amino-4-methylvalericacid
  • 1-Leucine
  • 2-Amino-4-methylpentanoic acid
  • 2-amino-4-methylpentanoicacid
  • 2-amino-4-methyl-valericaci
  • 4-methyl-l-norvalin
  • 4-methyl-norvalin
  • alpha-Amino-gamma-methylvaleric acid
  • alpha-amino-gamma-methylvalericacid
  • iso-C4H9CH(NH2)COOH
  • (S)-(+)-LEUCINE
  • (S)-2-AMINO-4-METHYLPENTANOIC ACID
  • RARECHEM AB PP 3754
  • L-A-AMINOISOCAPROIC ACID
  • L-A-AMINO-G-METHYL VALERIC ACID
  • L-2-AMINO-4-METHYLPENTANOIC ACID
  • L-2-AMINO-4-METHYLVALERIC ACID
  • L-LEU
  • L-(-)-LEUCINE
  • L-LEUCINE
  • LEUCINE, L-
  • LEU
  • LEUCINE
  • FEMA 3297
  • H-L-LEU-OH
  • H-LEU-OH
  • L-Leucine 99+ %
  • L-α-Aminoisocaproic acid
  • H-Leu-OH (L-Leucine)
  • L-LEUCINERESEARCH GRADE
  • L-Leucine,(S)-2-Amino-4-methylpentanoic acid, Leucinum
  • L-Leucine,(S)-2-Amino-4-methylpentanoic acid
  • L-Leucine, extra pure, Ph Eur, USP, BP
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  • EMPROVE(R) L-Leucine, USP, Ph Eur
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  • (S)-(+)-LEUCINE FOR SYNTHESIS
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  • Pentanoic acid, 2-amino-4-methyl-
  • Pentanoic acid, 2-amino-4-methyl-, (S)-
  • pentanoicacid,2-amino-4-methyl-,(S)-
  • Valeric acid, 2-amino-4-methyl-
  • α-amino-γ-methylvalericacid
  • L-Leucine USP24
  • L-LEUCINE SIGMAULTRA
  • L-LEUCINE SOLUTION INSECT CELL CULTURE*T ESTED
  • L-Leucine, 99% (97+% EE/GLC)
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