AG 1478

AG 1478 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.

Allgemeine Beschreibung

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC₅₀ >100 μM), the platelet-derived growth factor (PDGF) receptor (IC₅₀ >100 μM), and p210^Bcr-Abl (IC₅₀ >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Biochem/physiol Actions

Primary TargetEpidermal growth factor receptor kinase

AG 1478 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AG 1478 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
Shanghai Paulshine Chemical Co., Ltd.	+86-021-37788663		China	186	64
Jinan Trio PharmaTech Co., Ltd.	+86 (531) 88811783	sales@trio-pharmatech.com (International market)	China	1856	62
Spectrum Chemical Manufacturing Corp.	021-021-021-67601398-809-809-809 15221380277	marketing_china@spectrumchemical.com	China	9664	60
UHN Shanghai Research & Development Co., Ltd.	021-58958002 18930822973	SALES@UHNSHANGHAI.COM	China	977	58

175178-82-2()Verwandte Suche:

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• NSC 669364
• N-[3-CHLOROPHENYL]-6,7-DIMETHOXY-4-QUINAZOLINAMINE
• N-(3-CHLOROPHENYL)-N-(6,7-DIMETHOXY-4-QUINAZOLINYL)AMINE
• SU 5271
• WHI-P 79
• TYRPHOSTIN AG 1478
• TYRPHOSTIN AG 1517
• AG 1478
• AG 1517
• 4-(N-3-CHLOROPHENYL)-AMINO-6,7-DIMETHOXYQUINAZOLINE
• 4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-
• 4-(3-BROMOPHENYLAMINO)-6,7-BIS(METHOXY)QUINAZOLINE
• 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE
• 4-(3-BROMOPHENYLAMINO)-6,7-DIMETHYLQUINAZOLINE
• 4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE
• 4-(3-CHLOROANILLINO)-6,7-DIMETHOXYQUINAZOLINE
• 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE
• COMPOUND 32
• TYRPHOSTIN AG 1478, 99+%
• 4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline
• 4-Quinazolinamine,N-(3-chlorophenyl)-6,7-dimethoxy-
• N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
• Tyrphostin AG 1478, Methanesulfonate Salt
• InSolution? AG 1478
• PD-153,035
• Tyrphostin AG
• InSolution AG 1478 - CAS 175178-82-2 - Calbiochem
• AG 1478 - CAS 175178-82-2 - Calbiochem
• 4-[(3-chlorophenyl)methyl]-6,7-dimethoxyquinazoline
• AG 1478 USP/EP/BP
• 175178-82-2
• 174178-82-2
• BioChemical
• Cell Signaling and Neuroscience
• Cell Biology
• Kinase/Phosphatase Biology
• Epidermal Growth Factor Receptor (EGFR)
• Receptor Tyrosine Kinase Inhibitors