Suplatast tosilate

Suplatast tosilate Struktur
94055-76-2
CAS-Nr.
94055-76-2
Englisch Name:
Suplatast tosilate
Synonyma:
Suplatast tosylate;IPD-1151T;Suplatast;SUPLATAST TOSILATE;Suplatast Tosylate >Methotrexate Impurity 47;Suplatast tosilate USP/EP/BP;Suplatast Tosylate (IPD 1151T);TIANFU CHEM--Suplatast tosilate;N,N-dimethyl-2-propyl-1-pentanamine
CBNumber:
CB8837187
Summenformel:
C23H33NO7S2
Molgewicht:
499.64062
MOL-Datei:
94055-76-2.mol

Suplatast tosilate Eigenschaften

Schmelzpunkt:
84-87°C
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
DMSO: >20mg/mL
Aggregatzustand
powder
Farbe
white to off-white
Merck 
14,9003
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS Datenbank
94055-76-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. WR7906000
HS Code  2930.90.2900
Toxizität LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Suplatast tosilate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.

Verwenden

Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.

Biologische Aktivität

Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.

Suplatast tosilate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Suplatast tosilate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 163)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12452 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 6645 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
1012@dideu.com China 3911 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
WinWin Chemical CO., Limited
+86-0086-577-64498589 +86-15355981851
sales@win-winchemical.com China 13849 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58

94055-76-2()Verwandte Suche:


  • (2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate
  • 2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium·4-methylbenzenesulfonate
  • IPD-1151T
  • S,S-Dimethyl-3-oxo-3-[4-(2-hydroxy-3-ethoxypropoxy)anilino]propane-1-sulfonium·4-methylbenzenesulfonate
  • [2-[[[4-(2-Hydroxy-3-ethoxypropoxy)phenyl]amino]carbonyl]ethyl]dimethylsulfonium
  • [2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium
  • [3-Oxo-3-[4-(2-hydroxy-3-ethoxypropoxy)phenylamino]propyl]dimethylsulfonium
  • 2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium
  • N-[4-(2-Hydroxy-3-ethoxypropoxy)phenyl]-3-(dimethylsulfonio)propanamide
  • SUPLATAST TOSILATE
  • [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium4-methylbenzenesulfonate
  • Suplatast
  • [3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-sulfonium, 4-methylbenzenesulfonate (1:1)
  • N,N-dimethyl-2-propyl-1-pentanamine
  • Suplatast Tosylate >
  • High quality USP 39/EP 9.0 /BP 2012 GMP DMF FDA Suplatast tosilate CAS NO 18472-51-0 producer
  • Suplatast tosilate USP/EP/BP
  • Suplatast Tosylate (IPD 1151T)
  • TIANFU CHEM--Suplatast tosilate
  • Suplatast tosylate
  • Methotrexate Impurity 47
  • 94055-76-2
  • C16H26NO4SC7H7O3S
  • C16H26NO4SC7H7O3SC23H
  • C16H26NO4SC7H7O3SC23H33NO7S2
  • C23H33NO7S2
  • API
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • IPD 1151T
Copyright 2019 © ChemicalBook. All rights reserved