5-Methyluracil
|
|
|
- CAS-Nr.
- 65-71-4
- Bezeichnung:
- 5-Methyluracil
- Englisch Name:
- Thymine
- Synonyma:
- 5-Methylpyrimidine-2,4(1H,3H)-dione;THYMIN;5-METHYLURACIL;5-Methyl-2,4-dioxypyrimidine;Zidovudine Related CoMpound C;2,4-DIHYDROXY-5-METHYLPYRIMIDINE;5-Methyl-2,4(1H,3H)-pyrimidinedione;2,4(1H,3H)-Pyrimidinedione, 5-methyl-;hymine;THYMINE
- CBNumber:
- CB8854081
- Summenformel:
- C5H6N2O2
- Molgewicht:
- 126.11
- MOL-Datei:
- 65-71-4.mol
|
5-Methyluracil Eigenschaften
- Schmelzpunkt:
- ~320 °C (dec.) (lit.)
- Siedepunkt:
- 234.21°C (rough estimate)
- Dichte
- 1.3541 (rough estimate)
- Brechungsindex
- 1.5090 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Heated)
- Aggregatzustand
- Powder
- pka
- 9.94(at 25℃)
- Farbe
- White
- Wasserlöslichkeit
- Soluble in hot water. Slightly soluble in alcohol.
- Decomposition
- 335 °C
- Merck
- 14,9398
- BRN
- 607626
- Stabilität:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- RWQNBRDOKXIBIV-UHFFFAOYSA-N
- LogP
- -0.620
- CAS Datenbank
- 65-71-4(CAS DataBase Reference)
- NIST chemische Informationen
- Thymine(65-71-4)
- EPA chemische Informationen
- Thymine (65-71-4)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
5-Methyluracil Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White, crystalline powder. Slightly soluble in hot water; insoluble
in coldwater, alcohol; sparingly soluble in ether;
readily soluble in alkalies.
Verwenden
Thymine is a nitrogenous base component in the nucleic acid of DNA.
Definition
thymine: A pyrimidine derivativeand one of the major componentbases of nucleotides and the nucleicacid DNA.
Allgemeine Beschreibung
Thymine (Zidovudine Related Compound C) is a process related impurity of antiretroviral drug zidovudine. Zidovudine belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors and is generally used in the prevention and treatment of HIV/AIDS.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
läuterung methode
Crystallise thymine from EtOAc, 10% aqueous EtOH or water. It has m 318-320o after sublimation at 200o/12mm. Purify it by preparative (2mm thick) TLC plates of silica gel, eluting with ethyl acetate/isopropanol/water (75:16:9, v/v; RF 0.75). The desired spot is localated with a uv lamp, cut the band from the plate, place it in MeOH, shake and filter it through a millipore filter, then evaporate. [Infante et al. J Chem Soc, Faraday Trans 1 68 1586 1973, Beilstein 24 H 353, 24 I 330, 24 II 183, 24 III/IV 1292.]
5-Methyluracil Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Methyluracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 640)Lieferanten
65-71-4(5-Methyluracil)Verwandte Suche:
Sulfamerazin
2-(3,6-Dihydroxy-2,4,5,7-tetrabromxanthen-9-yl)-benzoesure
Triclosan
5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-on
1,3-Dimethylharnstoff
1,3-Dihydroxyaceton
2,6-Di-tert-butyl-p-kresol
2,4-Dichlor-5-methylpyrimidin
Etidronisure
3-Diethylaminophenol
Pirimiphos-methyl (ISO)
5-Methyluridin
6-Methyluracil
Trifluridin
5'-Thymidylsure, Dinatriumsalz
5-(Trifluormethyl)uracil
2,4-Dihydroxypyrimidin-5-carbonsure
5'-O-(p,p'-Dimethoxytrityl)thymidin
- 4(1H,3H)-Pyrimidinedione,5-methyl-2
- 5-Methylpyrimidine-2,4-dione
- thymin(purinebase)
- THYMINE
- LABOTEST-BB LT00848102
- THYMINE extrapure
- 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-
- 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chlorophenothiazin-10-yl)propyl]-
- 8-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
- Clospirazine
- Thymine,2,4-Dihydroxy-5-methylpyrimidine, 5-Methyluracil
- 2,6-Dioxy-5-Methyl- pyriMidine
- 5-Methyl-1H-pyrimidine-2,4-dione
- 5-Methylpyridine-2,4-(1H,3H)-dione
- ThyMine, 99% 100GR
- ThyMine, 99% 25GR
- ThyMine, 99% 5GR
- Zidovudine EP IMpurity C
- 2,4(1H,3H)-Pyrimidinedione,5-methyl-
- 2,4-Dihydroxy-5-methylpyrimidin
- 3h)-pyrimidinedione,5-methyl-4(1h
- METHYL(5-) URACIL
- 5-METHYLPYRIMIDINE-2,4-DIOL
- 5-METHYL-2,4-DIHYDROXYPYRIMIDINE
- 5-METHYL-1,2,4-DIHYDROXYPYRIMIDINE
- 2,4-DIHYDROXY-5-METHYLPYRIMIDINE 5-METHYLURACIL
- 2,4(1H,3H)-Pyrimidinedione, 5-methyl- (9CI)
- D-THYMIDINE
- THYMINE PLANT CELL CULTURE TESTED
- THYMINE CELL CULTURE TESTED
- Thymine,>99%
- ThymineForBiochemistry99+%
- Thymine(5-MethylUracil)
- Thymine, 97+%
- Thymine Vetec(TM) reagent grade, 99%
- Stavudine Impurit Ⅰ:5-Methyl-2,4(1H,3H)-pyrimidinedione( Thymine)
- Zidovudine ImpuritⅢ:ThyMine
- Zidovudine and Lamivudine Tablets Impurit Ⅲ:ThyMine
- Thymine(Zidovudine Related Compound C)
- Zidovudine EP Impurity C(Thymine)
- Zidovudine Impurity 3(Zidovudine EP Impurity C)
- Thymine >
- hymine
- Stavudine EP impurity A
- Zidovudine EP Impurity C/ Zidovudine Related Compound C (Stavudine EP Impurity A/ Thymine)
- Stavudine EP Impurity A (Zidovudine EP Impurity C/ Zidovudine Related Compound C/ Thymine)
- Thymine 98% (HPLC)
- Zidovudine Impurity CQ: What is
Zidovudine Impurity C Q: What is the CAS Number of
Zidovudine Impurity C Q: What is the storage condition of
Zidovudine Impurity C Q: What are the applications of
Zidovudine Impurity C
- Methylpyrimidine-2,4(1H,3H)-dione
- Zidovudine Related Compound C (thymine) (1724532)
- 5-Methyl-2,4(1H,3H)-pyrimidinedione
- THYMIN
- 5-Methylpyrimidine-2,4(1H,3H)-dione
- Zidovudine Related CoMpound C
- 5-METHYLURACIL
- 2,4-DIHYDROXY-5-METHYLPYRIMIDINE
- 5-Methyl-2,4-dioxypyrimidine
- 2,4(1H,3H)-Pyrimidinedione, 5-methyl-
