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8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Produkt Beschreibung

HOMATROPINE METHYL BROMIDE Struktur
80-49-9
CAS-Nr.
80-49-9
Bezeichnung:
8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)-
Englisch Name:
HOMATROPINE METHYL BROMIDE
Synonyma:
ESOPIN;sethyl;D02070;homapin;mesopin;Equipin;HOMOLONE;novatrin;sed-tems;endo-mid
CBNumber:
CB9114740
Summenformel:
C17H24BrNO3
Molgewicht:
370.28
MOL-Datei:
80-49-9.mol

8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Eigenschaften

Schmelzpunkt:
192°C
Löslichkeit
Freely soluble in water, soluble in ethanol 96 per cent
Aggregatzustand
neat
Merck 
14,4730
CAS Datenbank
80-49-9(CAS DataBase Reference)
EPA chemische Informationen
Homatropine methylbromide (80-49-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 20/21/22
S-Sätze: 22-26-36
RIDADR  1544
WGK Germany  3
RTECS-Nr. MS9000000
HazardClass  6.1
PackingGroup  III
HS Code  29399990
Toxizität LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White or almost white, crystalline powder or colourless crystals

Verwenden

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Verwenden

anticholinergic (opthalmic)

Trademarks

Equipin (Mission); Homapin (Mission).

Allgemeine Beschreibung

Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).

Clinical Use

Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.

8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 126)Lieferanten
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Henan DaKen Chemical CO.,LTD.
+86-371-66670886
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0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
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18071025641 18071025641
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AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58

80-49-9(8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)-)Verwandte Suche:


  • HOMOLONE
  • HOMATROPINE METHYL BROMIDE
  • ESOPIN
  • DL-HOMATROPINE METHYL BROMIDE
  • ARKITROPIN
  • 8-METHYLHOMATROPINIUM BROMIDE
  • N-METHYLHOMATROPINIUM BROMIDE
  • TROPINIUM METHOBROMIDE MANDELATE
  • 3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-8-azoniabicyclo(3.2.1)octanbro
  • 3-[(hydroxyphenylacetyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octanbromi
  • 3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromidemandelate
  • 8-methyl-homatropiniubromide
  • camatropine
  • dl-methylbromide
  • novatrin
  • novatrine
  • novatropine
  • sed-tems
  • sethyl
  • Homatropinmethylbromid
  • homatropine methobromide
  • Methyl Bromide Homatropine
  • 2-hydroxy-2-phenylacetic acid [(1S,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester bromide
  • endo-mid
  • homapin
  • homatromide
  • malcotran
  • mesopin
  • methylhomatropine
  • methylhomatropinebromide
  • Homotropine methylbromide
  • 8-Methylhomatropininium
  • Homatropine methyl
  • N-Methylhomatropinium
  • D02070
  • Equipin
  • Equipin (tn)
  • HoMatropinMethylbroMide
  • Homatropine Methylbromide (250 mg)
  • HoMatropineMeBr
  • Homatropine methylbromide, 99%, a muscarinic AChR antagonist
  • 8-Azoniabicyclo[3.2.1]octane, 3-[(2-hydroxy-2-phenylacetyl)oxy]-8,8-dimethyl-, bromide (1:1), (3-endo)-
  • Homatropine methylbromide for system suitability
  • Homatropine methylbromide CRS
  • Homatropine methylbromide for system suitability CRS
  • HOMATROPINE METHYL BROMIDE USP/EP/BP
  • Homatropine Methylbromide (Homatropine methobromide)
  • 80-49-9
  • C17H24NO3Br
  • C17H24BrNO3
  • C16H21NO3CH3Br
  • Tropane Alkaloids
  • Alkaloids
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
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