8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)-
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- CAS-Nr.
- 80-49-9
- Bezeichnung:
- 8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)-
- Englisch Name:
- HOMATROPINE METHYL BROMIDE
- Synonyma:
- D02070;ESOPIN;sethyl;Equipin;homapin;mesopin;HOMOLONE;novatrin;sed-tems;endo-mid
- CBNumber:
- CB9114740
- Summenformel:
- C17H24BrNO3
- Molgewicht:
- 370.28
- MOL-Datei:
- 80-49-9.mol
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8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Eigenschaften
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| R-Sätze: |
20/21/22 |
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| S-Sätze: |
22-26-36 |
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| RIDADR |
1544 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
MS9000000 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
29399990 |
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| Toxizität |
LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder or colourless crystals
Verwenden
Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.
Allgemeine Beschreibung
Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).
Clinical Use
Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.
8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 179)Lieferanten
80-49-9(8-Azoniabicyclo(3.2.1)octan,3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-, bromid, endo(+-)-)Verwandte Suche:
- methylhomatropine
- methylhomatropinebromide
- Homotropine methylbromide
- 8-Methylhomatropininium
- Homatropine methyl
- N-Methylhomatropinium
- D02070
- Equipin
- Equipin (tn)
- HoMatropinMethylbroMide
- Homatropine Methylbromide (250 mg)
- HoMatropineMeBr
- 8-Azoniabicyclo[3.2.1]octane, 3-[(2-hydroxy-2-phenylacetyl)oxy]-8,8-dimethyl-, bromide (1:1), (3-endo)-
- Homatropine methylbromide for system suitability
- HOMOLONE
- HOMATROPINE METHYL BROMIDE
- ESOPIN
- DL-HOMATROPINE METHYL BROMIDE
- ARKITROPIN
- 8-METHYLHOMATROPINIUM BROMIDE
- N-METHYLHOMATROPINIUM BROMIDE
- TROPINIUM METHOBROMIDE MANDELATE
- 3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-8-azoniabicyclo(3.2.1)octanbro
- 3-[(hydroxyphenylacetyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octanbromi
- 3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromidemandelate
- 8-methyl-homatropiniubromide
- camatropine
- dl-methylbromide
- novatrin
- novatrine
- novatropine
- sed-tems
- sethyl
- Homatropinmethylbromid
- homatropine methobromide
- Methyl Bromide Homatropine
- endo-mid
- homapin
- homatromide
- malcotran
- mesopin
- Homatropine methylbromide, 99%, a muscarinic AChR antagonist
- Homatropine methylbromide CRS
- Homatropine methylbromide for system suitability CRS
- HOMATROPINE METHYL BROMIDE USP/EP/BP
- Homatropine Methylbromide (Homatropine methobromide)
- Homatropine MethylbromideQ: What is
Homatropine Methylbromide Q: What is the CAS Number of
Homatropine Methylbromide Q: What is the storage condition of
Homatropine Methylbromide Q: What are the applications of
Homatropine Methylbromide
- Homatropine Methylbromide (1311000)
- 2-hydroxy-2-phenylacetic acid [(1S,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester bromide
- 80-49-9
- C17H24NO3Br
- C17H24BrNO3
- C16H21NO3CH3Br
- Tropane Alkaloids
- Alkaloids
- Amines
- Aromatics
- Heterocycles
