2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

114289-47-3

CAS-Nr.: 114289-47-3

Englisch Name:: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

Synonyma:: CI 976;PD 128042;CI-976 (PD 128042);N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide;2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE;2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid;Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-;inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor

CBNumber:: CB9130672

Summenformel:: C23H39NO4

Molgewicht:: 393.56

MOL-Datei:: 114289-47-3.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 69

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Eigenschaften

storage temp.: 2-8°C

Löslichkeit: DMSO: >10mg/mL

Aggregatzustand: solid

InChI: InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)

InChIKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N

SMILES: C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC₅₀ = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.

Verwenden

CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol

Biologische Aktivität

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 = 0.073 μ M). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidaemia. Orally active.

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 69)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

114289-47-3()Verwandte Suche:

Lauramid 2,4,6-Trimethoxyanilin

2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid
2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE
CI 976
PD 128042
N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide
CI-976 (PD 128042)
Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-
inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
114289-47-3
Miscellaneous Compounds
Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor.