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Licofelone

Licofelone Struktur
156897-06-2
CAS-Nr.
156897-06-2
Englisch Name:
Licofelone
Synonyma:
icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
CBNumber:
CB91385206
Summenformel:
C23H22ClNO2
Molgewicht:
379.88
MOL-Datei:
156897-06-2.mol
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Licofelone Eigenschaften

Schmelzpunkt:
162-163°C
Siedepunkt:
539.7±50.0 °C(Predicted)
Dichte
1.23
storage temp. 
-20°C Freezer
Löslichkeit
Chloroform, Methanol
pka
4.47±0.10(Predicted)
Aggregatzustand
Solid
Farbe
Off-White to Light Yellow
CAS Datenbank
156897-06-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Licofelone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Chemische Eigenschaften

Yellowish Solid

Licofelone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Licofelone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 117)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9352 55
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
Hubei Ipure Biology Co., Ltd 		+8613367258412
 ada@ipurechemical.com China 10326 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29474 58
AFINE CHEMICALS LIMITED 		0571-85134551
info@afinechem.com CHINA 15377 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9923 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418684 +8618949823763
 sales@tnjchem.com China 25363 58

156897-06-2()Verwandte Suche:

Dimethyl ether Dimethylsulfoxid Dimethylfumarat Dimethylsulfid Polyvinylpyrrolidone cross-linked N,N-Dimethylformamid 1-Vinyl-2-pyrrolidon Chlorthal-dimethyl Polyvinylpyrrolidone Ethan Dimethylcarbonat 1-Methyl-2-pyrrolidon Dimethylsulfat Pyrrolidin Sodium L-pyroglutamate 1-Methyl-1H-pyrrol-2-essigsure METHYL-2-PYRROLIDONE Chlorophenyl
  • 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • Licofelone, ML-3000
  • [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • ML 3000
  • 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
  • Licofelone
  • 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
  • 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-
  • Licofelone, >=99%
  • icofeL
  • Licofelone USP/EP/BP
  • 16-dihydrotanshinone I
  • 156897-06-2
  • C23H22ClNO2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors
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