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gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Produkt Beschreibung

Chlorpheniramine maleate  Struktur
113-92-8
CAS-Nr.
113-92-8
Bezeichnung:
gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)
Englisch Name:
Chlorpheniramine maleate
Synonyma:
Haynon;alunex;piriex;Puermin;c-meton;ibioton;lorphen;piriton;teldrin;Histadur
CBNumber:
CB9142008
Summenformel:
C20H23ClN2O4
Molgewicht:
390.86
MOL-Datei:
113-92-8.mol

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Eigenschaften

Schmelzpunkt:
130-135 °C (lit.)
alpha 
-1~+1°(D/20℃)(c=5,DMF)
Dichte
1.1984 (rough estimate)
Brechungsindex
1.6800 (estimate)
Flammpunkt:
9℃
storage temp. 
2-8°C
Löslichkeit
Freely soluble in water, soluble in ethanol (96 per cent)
Aggregatzustand
neat
PH
4.0~5.5 (10g/l, 25℃)
Wasserlöslichkeit
1-5 g/100 mL at 21 ºC
Merck 
14,2180
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
EPA chemische Informationen
Chlorpheniramine maleate (113-92-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,F
R-Sätze: 25-39/23/24/25-23/24/25-11
S-Sätze: 36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. US6504000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29333990
Toxizität LD50 orally in mice: 162 mg/kg (Smith)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P330 Mund ausspülen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

Chemische Eigenschaften

White Solid

Verwenden

Antihistaminic

Verwenden

An antagonist of the histamine H1-receptor

Verwenden

(±)-Chlorpheniramine maleate salt has been used:
  • as H1 receptor antagonist to determine the receptor function
  • to block the effect of compound 48/80 on plasma IGF-I
  • as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Trademarks

Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).

Allgemeine Beschreibung

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Allgemeine Beschreibung

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

Air & Water Reaktionen

Water soluble.

Reaktivität anzeigen

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Brandgefahr

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Biochem/physiol Actions

Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.

Sicherheitsprofil

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.

Dosage forms

4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 437)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9115 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58

113-92-8(gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1))Verwandte Suche:


  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate
  • 1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1)
  • Chlorophenamine
  • Chlorprophenpyridamine maleate
  • Cloropiril
  • Histadur
  • Histaspan
  • Puermin
  • Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1) (8CI)
  • (+-)-Chloropheniramine
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
  • 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 4-Chloropheniramine
  • 9: PN: US20030109453 SEQID: 8 claimed sequence
  • Allergican
  • Chlorophenylpyridamine
  • Chloroprophenpyridamine
  • Chlorprophenpyridamine
  • dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane
  • Haynon
  • RS-Chlorpheniramine
  • γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin maleate
  • 1-(p-chlorophenyl)-1-(2-pyridyl)-3-n,n-dimethylpropylamine
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
  • 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin
  • CHLOROPHENIRAMINE BASE
  • Chlorpheniramine (base and/or unspecified salts)
  • 1-(N,N-Dimethylamino)-3-(p-chlorophenyl)-3-(alpha-pyridyl)propane maleate
  • 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • Chlorphenamine hydrogen maleate
  • Chlorpheniramine maleate 113-92-8
  • Chlorpheniramine maleate, 99%, a histamine H1 receptor antagonist
  • 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
  • allerclor
  • allergin
  • alunex
  • antagonate
  • carbinoxamidemaleate
  • chlormene
  • chloroprophenpyridaminemaleate
  • chlor-tripolon
  • c-meton
  • dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioa
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
  • histadurdura-tabs
  • ibioton
  • lorphen
  • m.p.chlorcapst.d.
  • nci-c55265
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