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Succimer Produkt Beschreibung

Succimer Struktur
304-55-2
CAS-Nr.
304-55-2
Bezeichnung:
Succimer
Englisch Name:
Succimer
Synonyma:
DMSA;chemet;dim-sa;ro1-7977;SUCCIMER;MESO-DMSA;API Succimer;DMSA Succimer;Succimer USP/EP/BP;2,3-DITHIOSUCCINICACID
CBNumber:
CB9142563
Summenformel:
C4H6O4S2
Molgewicht:
182.22
MOL-Datei:
304-55-2.mol

Succimer Eigenschaften

Schmelzpunkt:
196-198 °C (dec.)(lit.)
Siedepunkt:
285.62°C (rough estimate)
Dichte
1.439 (estimate)
Brechungsindex
1.5220 (estimate)
storage temp. 
-20°C
pka
pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
Aggregatzustand
Powder
Farbe
White to off-white
Wasserlöslichkeit
Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck 
14,8865
BRN 
1725150
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS Datenbank
304-55-2(CAS DataBase Reference)
EPA chemische Informationen
Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 24/25-36-26
WGK Germany  2
RTECS-Nr. WM7650000
10-23
TSCA  Yes
HS Code  29309090
Giftige Stoffe Daten 304-55-2(Hazardous Substances Data)
Toxizität LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Succimer Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.

Chemische Eigenschaften

white or off-white powder

Originator

Johnson and Johnson (J&J) (U.S.A.)

Verwenden

Chelating agent.

Verwenden

A selective masking agent for cadmium in EDTA titration of zinc.

Verwenden

chelating agent, antihypertensive

Verwenden

meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.

Verwenden

chelating agent, treatment of lead poisoning

Verwenden

A water-soluble chelating agent.

Definition

ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.

Trademarks

Chemet (Ovation).

Pharmazeutische Anwendungen

Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.

Pharmazeutische Anwendungen

The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.

Veterinary Drugs and Treatments

In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended.

läuterung methode

Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]

Succimer Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Succimer Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 353)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
86-27-59524646 info@fortunachem.com CHINA 3073 58
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 154 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5942 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58

304-55-2(Succimer)Verwandte Suche:


  • (2R,3S)-2,3-diMercaptosuccinic acid
  • (2R,3S)-rel-2,3-DiMercaptosuccinic acid
  • Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel-
  • meso-2,3-Dimercaptosuccinic acid
  • API Succimer
  • -rel-2,3-Dimercaptosuccinic acid
  • (2S,3R)-2,3-dimercaptobutanedioate
  • (r*,s*)-2,3-dimercaptobutanedioicacid
  • 2,3-dimercapto-,(r*,s*)-butanedioicaci
  • 2,3-dimercapto-,(theta,s)-butanedioicaci
  • 3-dimercapto-meso-succinicaci
  • 2,3-DITHIO-MESO-TARTARIC ACID
  • 2,3-BIS-SULFANYLBUTANEDIOIC ACID
  • 2,3-DIMERCAPTOSUCCINICACIDMESO
  • MESO-DMSA
  • 2,3-DITHIOSUCCINICACID
  • 2,3-dimercapto-, ( theta,s)-butanedioic acid
  • 2,3-dimercapto-, (r*,s*)-butanedioic acid
  • 3-dimercapto- meso-succinic acid
  • MESO-2,3-DIMERCAPTOSUCCINIC ACIDF&D VERS ION
  • MESO-2,3-DIMERCAPTO SUCCINIC ACID ENTERPRISE STANDARD =98.5%
  • DimercaptosuccinicAcid(Dmsa)
  • 2,3-Dimercaptosuccinic
  • rel-(2R,3S)-2,3-Dimercaptobutanedioic acid
  • chemet
  • dim-sa
  • meso-2,3-dithiosuccinicacid
  • meso-dimercaptosuccinicacid
  • ro1-7977
  • SUCCIMER
  • DMSA
  • MESO-2,3-DIMERCAPTOSUCCINIC ACID
  • meso-2,3-Dimercaptosuccinic acid,98%
  • 2,3-DIMERCAPTO SUCCINIC ACID (DMSA) extrapure
  • 2,3-Dithio-meso-tartaric acid, DMSA, Succimer
  • meso-2,3-Dimercaptosuccinic acid,2,3-Dithio-meso-tartaric acid, DMSA, Succimer
  • Meso-2,3-DiMercaptosuccinic acid(DMSA,SucciMer)
  • DMSA (Meso-2,3-diMercaptosuccinic acid)
  • Meso-2,3-DiMercaptosuccinic acid, 98% 5GR
  • meso-2,3-DimercaptosuccinicAcid>
  • DMSA Succimer
  • Succimer USP/EP/BP
  • meso-2,3-Dimercaptosuccinic acid (DMSA)
  • Best Price Dmsa Powder Dimercaptosuccinic Acid?304-55-2
  • 304-55-2
  • HO2CCHSHCHSHCO2H
  • C4H4O4S2
  • C4H6O4S2
  • Building Blocks
  • Radiopharmaceutical Chemistry (Chelating Reagents)
  • Ligands for Pharmaceutical Research
  • Organic Building Blocks
  • Sulfur Compounds
  • Thiols/Mercaptans
  • API
  • Inhibitors
  • Organic acids
  • Analytical Chemistry
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