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Succimer Produkt Beschreibung

CAS-Nr.304-55-2
Bezeichnung:Succimer
Englisch Name:Succimer
Synonyma:
DMSA;chemet;dim-sa;ro1-7977;SUCCIMER;MESO-DMSA;API Succimer;2,3-Dimercaptosuccinic;2,3-DITHIOSUCCINICACID;meso-2,3-dithiosuccinicacid
CBNumber:CB9142563
Summenformel:C4H6O4S2
Molgewicht:182.22
MOL-Datei:304-55-2.mol
Succimer physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 196-198 °C (dec.)(lit.)
Siedepunkt:: 285.62°C (rough estimate)
Dichte: 1.439 (estimate)
Brechungsindex: 1.5220 (estimate)
storage temp. : −20°C
Aggregatzustand: Powder
pka: pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
Farbe: White to off-white
Wasserlöslichkeit: Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck : 14,8865
BRN : 1725150
Stabilität:: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS Datenbank: 304-55-2(CAS DataBase Reference)
EPA chemische Informationen: Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel-(304-55-2)
Sicherheit
Kennzeichnung gefährlicher: Xi
R-Sätze:: 36/37/38
S-Sätze:: 24/25-36-26
WGK Germany : 2
RTECS-Nr.: WM7650000
F : 10-23
TSCA : Yes
HS Code : 29309090
Giftige Stoffe Daten: 304-55-2(Hazardous Substances Data)
Toxizität: LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)

Succimer Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.
Chemische Eigenschaften
white or off-white powder
Originator
Johnson and Johnson (J&J) (U.S.A.)
Verwenden
Chelating agent.
Verwenden
A selective masking agent for cadmium in EDTA titration of zinc.
Verwenden
chelating agent, antihypertensive
Verwenden
meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.
Verwenden
chelating agent, treatment of lead poisoning
Verwenden
A water-soluble chelating agent.
Definition
ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
Trademarks
Chemet (Ovation).
Pharmazeutische Anwendungen
Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.
Pharmazeutische Anwendungen
The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.
läuterung methode
Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]
Succimer Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2,3-Dibrombernsteinsure
Downstream Produkte
Succimer Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 240)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.comsales1@qqpharm.com CHINA 176 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 303 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093export@haihangchem.com CHINA 4660 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 299 58
BOC Sciences
info@bocsci.com United States 10515 65
 
304-55-2(Succimer)Verwandte Suche:
ACETIC ACID 2-Mercaptoethanol (2-Ethylhexyl)-thioglykolat Thioglykolsäure Calciumthioglykolat Propan-1,2-dithiol Butan-2,3-dithiol Dimercaprol 2,3-Dimercaptobernsteinsure Mercaptobernsteinsäure Succimer Kaliummercaptoacetat 3-Mercaptopropionsäure Dinatriumsuccinat Folsure ASCORBICACID Bernsteinsure Zitronensure
(r*,s*)-2,3-dimercaptobutanedioicacid 2,3-dimercapto-,(r*,s*)-butanedioicaci 2,3-dimercapto-,(theta,s)-butanedioicaci 3-dimercapto-meso-succinicaci 2,3-DITHIO-MESO-TARTARIC ACID 2,3-BIS-SULFANYLBUTANEDIOIC ACID MESO-2,3-DIMERCAPTOSUCCINIC ACIDF&D VERS ION MESO-2,3-DIMERCAPTO SUCCINIC ACID ENTERPRISE STANDARD =98.5% DimercaptosuccinicAcid(Dmsa) 2,3-Dimercaptosuccinic 2,3-DIMERCAPTOSUCCINICACIDMESO MESO-DMSA chemet dim-sa meso-2,3-dithiosuccinicacid meso-dimercaptosuccinicacid ro1-7977 SUCCIMER (2R,3S)-2,3-diMercaptosuccinic acid (2R,3S)-rel-2,3-DiMercaptosuccinic acid Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel- meso-2,3-Dimercaptosuccinic acid API Succimer -rel-2,3-Dimercaptosuccinic acid 2,3-DITHIOSUCCINICACID 2,3-dimercapto-, ( theta,s)-butanedioic acid 2,3-dimercapto-, (r*,s*)-butanedioic acid 3-dimercapto- meso-succinic acid DMSA MESO-2,3-DIMERCAPTOSUCCINIC ACID Organic Building Blocks Sulfur Compounds Thiols/Mercaptans HO2CCHSHCHSHCO2H 2,3-DIMERCAPTO SUCCINIC ACID (DMSA) extrapure 2,3-Dithio-meso-tartaric acid, DMSA, Succimer meso-2,3-Dimercaptosuccinic acid,98% meso-2,3-Dimercaptosuccinic acid,2,3-Dithio-meso-tartaric acid, DMSA, Succimer DMSA (Meso-2,3-diMercaptosuccinic acid) Meso-2,3-DiMercaptosuccinic acid, 98% 5GR Meso-2,3-DiMercaptosuccinic acid(DMSA,SucciMer) Analytical Chemistry Ligands for Pharmaceutical Research Radiopharmaceutical Chemistry (Chelating Reagents) Building Blocks Chemical Synthesis Organic Building Blocks Sulfur Compounds Thiols/Mercaptans Inhibitors API 304-55-2 C4H6O4S2 Building Blocks Radiopharmaceutical Chemistry (Chelating Reagents) Ligands for Pharmaceutical Research Organic acids
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