Avanafil
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- CAS-Nr.
- 330784-47-9
- Englisch Name:
- Avanafil
- Synonyma:
- Stendra;vanafil;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;(S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;U 53;U-53;D03217;avanfil;AVANAFE;Avanafil
- CBNumber:
- CB91503998
- Summenformel:
- C23H26ClN7O3
- Molgewicht:
- 483.95
- MOL-Datei:
- 330784-47-9.mol
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Avanafil Eigenschaften
- Schmelzpunkt:
- 150-152°C
- Dichte
- 1.372
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- pka
- 11.84±0.46(Predicted)
- Farbe
- White to Off-White
- InChIKey
- WEAJZXNPAWBCOA-INIZCTEOSA-N
- SMILES
- C1(N2CCC[C@H]2CO)=NC=C(C(NCC2=NC=CC=N2)=O)C(NCC2=CC=C(OC)C(Cl)=C2)=N1
- CAS Datenbank
- 330784-47-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Avanafil Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Avanafil (Zepeed) was approved by the Korean Health Ministry for the
treatment of erectile dysfunction (ED) in August 2011. Avanafil is a
highly selective type 5 phosphodiesterase (PDE5) inhibitor.
Avanafil is reported to be the most selective PDE5
inhibitor on the market. The onset of Tmax and half-life also varies among
the marketed PDE5 inhibitors. Sildenafil has a T
max at 1 h and a half-life of
3–5 h. Vardenafil is somewhat similar with a T
max of 0.6 h and a half-life of
4–6 h. Tadalafil has the longest half-life among the marketed drugs with a
half-life of 17 h. Avanafil has a fast onset of action reaching T
max in 0.6 h
with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described
in the patent literature. The main elimination route of avanafil
is through the bile and feces. Avanafil was also found to be reabsorbed
through enterohepatic recirculation.
Chemische Eigenschaften
White Solid
Verwenden
Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine
Used for treatment of erectile dysfunction.
Clinical Use
Avanafil was originally discovered at Tanabe Seiyaku (now
Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil,
which is an oral PDE5 inhibitor for the treatment of erectile dysfunction
(ED). Although many marketed PDE5 inhibitors (e.g. sildenafil,
vardenafil and tadalafil) are available for the treatment of ED,
many patients are still unable to achieve the desired results and
experience undesired side-effects with these existing medications.
As such, second-generation PDE5 inhibitors with enhanced PDE5
selectivity, shorter systemic half-lives, and improved tolerability
are desired. Developed to meet these criteria, Avanafil exhibited
good oral bioavailability and PDE5 selectivity in both preclinical
studies and clinical trials. Avanafil had a short onset of action
(35 min) and short half-life (1.5 h).
Avanafil Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Avanafil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 428)Lieferanten
330784-47-9()Verwandte Suche:
- 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]
aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
- Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
- avanfil
- (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl
- avanafil:4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide: (s)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylami
- (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide
- (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
- 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
- Avanafil
- Avanafil (usan/inn)
- D03217
- Avanafil PDE5 inhibitor
- pharmaceutical raw material suppliers Avanafil 330784-47-9 high quality lower Prices
- Natural Sex Steroid Hormones Avanafil Hormone Powder C23H26ClN7O3 CAS 330784-47-9
- Avanafil-d3
- 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
- Avanafil(TA-1790)
- 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
- [13C5, 15N]-Avanafil
- 4-[(3-Chloro-4-methoxybenzyl)amino]
- O cut the non
- AVANAFE
- Avanafil white powder
- Avanafil USP/EP/BP
- Avanafil , Stendra
- Avanafil, Standa
- (S)-4-chloro-6-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
- 4-[(3-Chloro-4-methoxybenzyl)amino] Avanafil
- Avanafil-d4
- (S)-4-chloro-6-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-6-carboxamide
- AvanafilQ: What is
Avanafil Q: What is the CAS Number of
Avanafil Q: What is the storage condition of
Avanafil Q: What are the applications of
Avanafil
- Avanafil 13C5 15NQ: What is
Avanafil 13C5 15N Q: What is the CAS Number of
Avanafil 13C5 15N Q: What is the storage condition of
Avanafil 13C5 15N Q: What are the applications of
Avanafil 13C5 15N
- U 53
- U-53
- vanafil
- Stendra
- 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
- (S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
- 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(S)-2-(hydroxymethyl)-1-pyrrolidyl]-N-[(2-pyrimidyl)methyl]-5-pyrimidinecarboxamide
- 330784-47-9
- C23H26ClN7O3
- Avanafil
- Inhibitor
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Aromatics
- Chiral Reagents
- Heterocycles
- Inhibitors
- API
- 330784-47-9
