3-Fluoro-4-nitrobenzoic acid
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- CAS-Nr.
- 403-21-4
- Englisch Name:
- 3-Fluoro-4-nitrobenzoic acid
- Synonyma:
- BUTTPARK 32\01-75;3-Fluoro-4-nitrobenzoic;uoro-4-nitrobenzoic Acid;3-FLUORO-4-NITROBENZONICACID;3-FLUORO-4-NITROBENZOIC ACID;3-FLUORO-4-NITROBENZOIC CAID;3-Fluoro-4-nitrobenzoicacid95%;3-Fluoro-4-nitrobenzoicacid99%;4-Carboxy-2-fluoronitrobenzene;3-Fluoro-4-nitrobenzoicAcid>
- CBNumber:
- CB9155507
- Summenformel:
- C7H4FNO4
- Molgewicht:
- 185.11
- MOL-Datei:
- 403-21-4.mol
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3-Fluoro-4-nitrobenzoic acid Eigenschaften
- Schmelzpunkt:
- 174-175°C
- Siedepunkt:
- 372.8±27.0 °C(Predicted)
- Dichte
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- soluble in Methanol
- Aggregatzustand
- powder to crystal
- pka
- 3.08±0.10(Predicted)
- Farbe
- White to Light yellow to Green
- InChI
- InChI=1S/C7H4FNO4/c8-5-3-4(7(10)11)1-2-6(5)9(12)13/h1-3H,(H,10,11)
- InChIKey
- WVZBIQSKLXJFNX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C([N+]([O-])=O)C(F)=C1
- CAS Datenbank
- 403-21-4(CAS DataBase Reference)
3-Fluoro-4-nitrobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R37/38:Reizt die Atmungsorgane und die Haut.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S37:Geeignete Schutzhandschuhe tragen.
Verwenden
3-Fluoro-4-nitrobenzoic Acid is used in the synthesis of ABT-072, a non-nucleoside HCV NS5B polymerase inhibitor.
Synthese
To a solution of 3-fluoro-4-nitrobenzyl alcohol (2.97 g) in acetone (60 ml) was added Jones reagent (13 ml), prepared from chromic acid (26.7 g) and sulfuric acid (23 ml) in water (100 ml), dropwise at 0°C. The mixture was stirred on a ice-bath for 0.5 h and quenched with isopropanol (20 ml) to be concentrated in vacuo. The residue was dissolved in ethyl acetate (30 ml) and washed with water (30 ml X 3), and brine (30 ml X 1), successively. The organic layer was dried over sodium sulfate and concentrated in vacuo to obtain a yellow solid, that was triturated with hexane. 3-fluoro-4-nitrobenzoic acid as a pale yellow solid (2.94 g, 92%).
3-Fluoro-4-nitrobenzoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Fluoro-4-nitrobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 296)Lieferanten
403-21-4()Verwandte Suche:
- 3-FLUORO-4-NITROBENZENECARBOXYLIC ACID
- 3-FLUORO-4-NITROBENZOIC ACID
- BUTTPARK 32\01-75
- 3-FLUORO-4-NITROBENZONICACID
- 3-Fluoro-4-nitrobenzoicacid95%
- 3-Fluoro-4-nitrobenzoic
- 3-Fluoro-4-nitrobenzoic acid 99%
- 3-Fluoro-4-nitrobenzoicacid99%
- 3-Fluoro-4-nitrobenzoic acid, 98+%
- 3- fluorine-4-Nitrobenzoic Acid
- 4-Carboxy-2-fluoronitrobenzene
- 3-Fluoride-4-Nitro Benzoic Acids
- 3-Fluoro-4-nitrobenzoicAcid>
- Benzoic acid, 3-fluoro-4-nitro-
- uoro-4-nitrobenzoic Acid
- 3-FLUORO-4-NITROBENZOIC CAID
- 403-21-4
- 403-21-1
- Carboxylic Acids
- Phenyls & Phenyl-Het
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- Miscellaneous
- blocks
- Carboxes
- FluoroCompounds
- NitroCompounds
- Acids and Derivatives
