ChemicalBook
Chinese english Germany Japanese Korea

FMOC-LYS(IVDDE)-OH Produkt Beschreibung

FMOC-LYS(IVDDE)-OH Struktur
204777-78-6
CAS-Nr.
204777-78-6
Englisch Name:
FMOC-LYS(IVDDE)-OH
Synonyma:
Fmoc-Lys(Ddiv)-OH;FMOC-LYS(IVDDE)-OH;Fmoc-Lys(ivDde)-0H;FMOC-L-LYS(IVDDE)-OH;FMOC-LYSINE(IVDDE)-OH;FMoc-Lys(Ddiv)-OHFMoc-Ly;Fmoc-Lys(ivDde)-OH Novabiochem;(9H-Fluoren-9-yl)MethOxy]Carbonyl L-Lys(ivDde)-OH;N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine;FMOC-N-EPSILON-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-LYSINE
CBNumber:
CB9168561
Summenformel:
C34H42N2O6
Molgewicht:
574.71
MOL-Datei:
204777-78-6.mol

FMOC-LYS(IVDDE)-OH Eigenschaften

storage temp. 
2-8°C
Aggregatzustand
Powder
Farbe
White
InChIKey
PYCBVLUBTMHNPW-MHZLTWQESA-N

Sicherheit

WGK Germany  3
10-21
HS Code  2924 29 70

FMOC-LYS(IVDDE)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fmoc-lys(IVDDE)-OH is a kind of FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It is important during peptide manufacturing. It is mainly used for the production of peptides which required to be modified on the Lysine side chain, including peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys side chain. It can also be used for the manufacturing of anionic cell penetrating peptide which is useful for intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed thorough hydrazine in the presence of acid labile groups.

Chemische Eigenschaften

White to pale yellow powder

Verwenden

ivDde = 1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde.

Verwenden

Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.

Einzelnachweise

Wen-Qu, L. I., X. U. Hong-Yan, and L. I. Zhan-Xiong. "Synthesis of End N-Ivdde Protected Amino Acid."Chinese Journal of Synthetic Chemistry 17.2(2009):213-215.
http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid.php?id=101224
Chen, Hui Ting, et al. "Anionic cell penetrating peptide and its use for intracellular delivery." US, US8614194. 2013.

FMOC-LYS(IVDDE)-OH Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FMOC-LYS(IVDDE)-OH Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 95)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 1954 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21753 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24192 60
GenicBio Limited
+86-21-37621270
+86-21-67621877 service@genicbio.com CHINA 991 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Jinan Carbotang Biotech Co.,Ltd.
+86 15866703830
+86 0531-61324629 figo.gao@foxmail.com CHINA 503 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23964 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58

  • Fmoc-Lys(Ddiv)-OH
  • (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)hexanoic acid
  • FMoc-Lys(ivDde)-OH N-α-FMoc-N-ε-1-(4,4-diMethyl-2,6-dioxocyclohex-1 -ylidene)-3-Methylbutyl-L-lysine
  • FMoc-Lys(Ddiv)-OHFMoc-Ly
  • Nα-Fmoc-Nε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine≥ 99.9% (HPLC, Chiral purity)
  • Fmoc-Lys(ivDde)-OH Novabiochem
  • Nalpha-Fmoc-Nepsilon-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-L-lysine
  • FMOC-N-EPSILON-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-LYSINE
  • FMOC-LYSINE(IVDDE)-OH
  • FMOC-LYS(IVDDE)-OH
  • FMOC-L-LYS(IVDDE)-OH
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-LYSINE
  • N-ALPHA-(9-FLUORENYL)METHOXYCARBONYL)-N-EPSILON-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE-3-METHYLBUTYL]-L-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-LYSINE
  • N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl L-Lys(ivDde)-OH
  • Fmoc-Lys(ivDde)-0H
  • (2S)-6-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid
  • 204777-78-6
  • 204777-78-4
  • C34H42N2O6
  • Amino Acid Derivatives
  • Lysine
  • Specialty Synthesis
  • Peptide Synthesis
  • amino acid
  • amino acids
  • -
Copyright 2019 © ChemicalBook. All rights reserved