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2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Struktur
763114-26-7
CAS-Nr.
763114-26-7
Englisch Name:
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
Synonyma:
EOS-61877;Olapali impurity 25;Olaparib Intermediate 1;Olaparib intermediate 763114-26-7;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...
CBNumber:
CB92554162
Summenformel:
C16H11FN2O3
Molgewicht:
298.27
MOL-Datei:
763114-26-7.mol
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2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Eigenschaften

Dichte
1.42
storage temp. 
Sealed in dry,Room Temperature
pka
3.19±0.10(Predicted)
Aggregatzustand
powder
Farbe
White to off-white
InChI
InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)
InChIKey
PAXLJNGPFJEKQX-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(CC2C3=C(C=CC=C3)C(=O)NN=2)=CC=C1F
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2916399090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.

Application

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.

Synthese

Synthesis_763114-26-7
Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-FLUORO-5-FORMYLBENZOIC ACID 95 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Phthalaldehydsure

Downstream Produkte

Fluzoparib AZD2461

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 285)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
PharmOrgSyn Laboratories Co., Ltd.
+86-021-38228826 +86-13916602830
 sales@pharmorgsyn.cn China 140 58
Shanghai Rochi Pharmaceutical Co.,Ltd.
21-38751876 +8615000076078
 info@rochipharma.com China 431 58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
+86-18616643091 +86-18616643091
 info@rochipharma.com China 246 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 7845 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60

763114-26-7()Verwandte Suche:

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  • Olaparib intermediate 763114-26-7
  • 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...
  • C16H11FN2O3 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
  • -Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid
  • Olaparib Intermediate 1
  • 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-yl)methyl] benzoic acid
  • Olapali impurity 25
  • 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicaci
  • 763114-26-7
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