Azelastine hydrochloride
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- CAS-Nr.
- 79307-93-0
- Englisch Name:
- Azelastine hydrochloride
- Synonyma:
- AZELASTINE HCL;Astelin;Optivar;1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride;4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, hydrochloride (1:1);Azen;a5610;e-0659;Azepit;w-2979m
- CBNumber:
- CB9256008
- Summenformel:
- C22H25Cl2N3O
- Molgewicht:
- 418.36
- MOL-Datei:
- 79307-93-0.mol
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Azelastine hydrochloride Eigenschaften
- Schmelzpunkt:
- 225--2290C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Merck
- 14,906
- Stabilität:
- Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
- InChIKey
- YEJAJYAHJQIWNU-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(Cl)C=C2)=NN1C1CCCN(C)CC1.[H]Cl
- CAS Datenbank
- 79307-93-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| RTECS-Nr. |
TH9203900 |
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| HS Code |
2933992600 |
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| Toxizität |
LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Azelastine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Orally active H1-hystamine receptor antagonist. Antihistaminic
Definition
ChEBI: The hydrochloride salt of azelastine.
Allgemeine Beschreibung
(±)-4-[(4-chlorophenyl)methyl]-2-(hexahydro-l-methyl-1H-azepin-4-yl)-l-(2H)-phthalazinone monohydrochloride (Optivar), is a whitecrystalline powder that is sparingly soluble in water,methanol, and propylene glycol and slightly soluble inethanol, octanol, and glycerine. The commercial preparationis available as a 0.05% sterile ophthalmic solution fortopical administration to the eyes. Each milliliter of azelastinesolution contains 0.5-mg azelastine hydrochlorideequivalent to 0.457 mg of azelastine base, the preservativebenzalkonium chloride (0.125 mg), and inactive ingredientsincluding disodium edetate dihydrate, hydroxypropylmethylcellulose,sorbitol solution, sodium hydroxide, andwater for injection. The solution has a pH of approximately5.0 to 6.5 and an osmolality of approximately 271to 312 mOsm/L.
The recommended dose of azelastine solution is 1 dropinstilled into each affected eye twice a day. This drugproduct is for ocular administration only and not for injectionor oral use. Absorption of azelastine following ocularadministration is relatively low (less than 1 ng/rnL).Absorbed drug undergoes extensive oxidative N-demethylationby CYP, and the parent drug and metabolite are eliminatedprimarily in the feces. The most frequently reportedadverse reactions are transient eye burning or stinging,headaches, and bitter taste. Azelastine solution should beused with caution during pregnancy or while nursing, becauseits safety has not been studied under these circumstances.
Sicherheitsprofil
Poison by ingestion andintravenous routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and HCl.
Azelastine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Azelastine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 384)Lieferanten
79307-93-0()Verwandte Suche:
- a5610
- azeptin
- e-0659
- w-2979m
- AZELASTINE HYDROCHLORIDE
- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride
- 4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride
- Allergodil
- Optilast
- Rhinolast
- Aselastine
- Acelastine hydrochloride
- Adomessen
- Asutoputin
- Azen
- Azepit
- Azelastine HCI
- Azelastine-d4 hydrochloride
- AZWLASTINE HYDROCHLORIDE API
- 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)-1-phthalazinone Hydrochloride
- Azelastine hydrochloride (Allergodil)
- Azelastine-d4 HCl
- Azelastine HCl (Allergodil)
- Azelastine hydrochloride CRS
- Azelastine Hydrochloride >
- 4-hydrazineyl-1-methylazepane hydrogen chloride
- 4-(4-Chlorobenzyl)-2-[(4RS)-1-methylhexahydro-1H-azepin-4-yl]phthalazin-1(2H)-one hydrochloride
- Azelastine hydrochloride USP/EP/BP
- Azelastine hydrochloride (API)
- Azelastine HydrochlorideQ: What is
Azelastine Hydrochloride Q: What is the CAS Number of
Azelastine Hydrochloride Q: What is the storage condition of
Azelastine Hydrochloride
- Azelastine Hydrochloride (1046158)
- AZELASTINE HCL
- Astelin
- 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride
- 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, hydrochloride (1:1)
- Optivar
- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one hydrochloride
- 79307-93-0
- C22H24ClN3OHCl
- C22H27Cl2N3O
- C22H25Cl2N3O
- C22H24ClN3OClH
- Antihistaminic
- Astelin
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Histamine receptor
