SMER 28
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- CAS-Nr.
- 307538-42-7
- Englisch Name:
- SMER 28
- Synonyma:
- CS-2308;SMER 28;SMER-28;SMER 28;N-Allyl-6-bromoquinazolin-4-amine;SMER28 - CAS 307538-42-7 - Calbiochem;6-BroMo-N-2-propenyl-4-QuinazolinaMine;6-Bromo-N-prop-2-enylquinazolin-4-amine;6-BroMo-N-2-propen-1-yl-4-quinazolinaMine;4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
- CBNumber:
- CB92561083
- Summenformel:
- C11H10BrN3
- Molgewicht:
- 264.12
- MOL-Datei:
- 307538-42-7.mol
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SMER 28 Eigenschaften
- Schmelzpunkt:
- 171-173 °C
- Siedepunkt:
- 391.6±32.0 °C(Predicted)
- Dichte
- 1.520±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: >20mg/mL
- Aggregatzustand
- solid
- pka
- 6.12±0.50(Predicted)
- Farbe
- Beige
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
SMER 28 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. SMER 28 increases autophagosome synthesis and enhances clearance of model autophagy substrates such as A5
3T α-synuclein associated with Huntington's disease.
Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.
SMER 28 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SMER 28 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 94)Lieferanten
307538-42-7()Verwandte Suche:
- SMER 28
- 6-BroMo-N-2-propen-1-yl-4-quinazolinaMine
- 6-BroMo-N-2-propenyl-4-QuinazolinaMine
- 6-Bromo-N-prop-2-enylquinazolin-4-amine
- SMER28 - CAS 307538-42-7 - Calbiochem
- CS-2308
- SMER-28;SMER 28
- 4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
- N-Allyl-6-bromoquinazolin-4-amine
- 307538-42-7
- API
