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AT-406(AT406)

AT-406(AT406) Struktur
1071992-99-8
CAS-Nr.
1071992-99-8
Englisch Name:
AT-406(AT406)
Synonyma:
Xevinapant;SM 406;QCR-136;Debio-1143;SureCN2724374;AT-406(AT406);CHEMBL2158051;AT-406 (SM-406);AT-406（Xevinapant）;Xevinapant (AT406)
CBNumber:
CB92630066
Summenformel:
C32H43N5O4
Molgewicht:
561.71
MOL-Datei:
1071992-99-8.mol
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AT-406(AT406) Eigenschaften

Siedepunkt:
840.6±65.0 °C(Predicted)
Dichte
1.21
storage temp. 
Store at -20°C
Löslichkeit
≥27.65 mg/mL in DMSO; insoluble in H2O; ≥27 mg/mL in EtOH
Aggregatzustand
solid
pka
13.65±0.40(Predicted)
InChIKey
LSXUTRRVVSPWDZ-MKKUMYSQSA-N
SMILES
N12[C@H](C(NC(C3=CC=CC=C3)C3=CC=CC=C3)=O)CC[C@]1([H])CCN(C(=O)CC(C)C)C[C@H](NC(=O)[C@@H](NC)C)C2=O

Sicherheit

RIDADR  3077
HS Code  29339900

AT-406(AT406) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AT-406 is an orally bioavailable Smac/DIABLO mimetic and antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to XIAP, cIAP1, and cIAP2 proteins with Ki values of 66.4, 1.9, and 5.1 nM, respectively. It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce apoptosis in xenograft tumors in mice.

Verwenden

AT-406 is a potent IAP (inhibitor of apoptosis protein) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

AT-406(AT406) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AT-406(AT406) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 101)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
 masar@topule.com China 8474 58
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 967 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63711 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
  • AT-406(AT406)
  • (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(MethylaMino)propanaMido)-3-(3-Methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxaMide
  • SM 406
  • (5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamide
  • AT406 (SM-406, ARRY-334543)
  • (5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamide AT406 (SM-406, ARRY-334543)
  • (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahyd
  • AT-406 (SM-406)
  • CHEMBL2158051; AT406; AT 406; SURECN2724374; QCR-136; SM406; SM 406; AT406 (SM-406)
  • QCR-136
  • SureCN2724374
  • CHEMBL2158051
  • Debio-1143
  • SM-406;DEBIO-1143;ARRY-334543
  • Pyrrolo[1,2-a][1,5]diazocine-8-carboxamide, N-(diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxo-, (5S,8S,10aR)-
  • AT-406（Xevinapant）
  • AT406 (Xevinapant, SM406, ARRY334543)
  • Xevinapant
  • SM 406,SM406,Xevinapant,AT-406,oral,inhibit,Debio 1143,ovarian,IAP,degradation,Smac,AT 406,Inhibitor,cancer,mimetic,Debio1143
  • Xevinapant (AT406)
  • 1071992-99-8
  • C32H43N5O4
  • Inhibitor
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