N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide

942206-85-1

CAS-Nr.: 942206-85-1

Englisch Name:: N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide

Synonyma:: GSK101;CS-2774;GSK1016790A;GSK1016790A(GSK101);GSK-1016790A;GSK 1016790A;GSK1016790A;GSK-1016790A;GSK 1016790A;N-((S)-1-(4-(((2,4-dichlorophenyl)sulfonyl)-L-seryl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxamide;N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide;(N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide;Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-

CBNumber:: CB92676060

Summenformel:: C28H32Cl2N4O6S2

Molgewicht:: 655.61

MOL-Datei:: 942206-85-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 88

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Eigenschaften

Schmelzpunkt:: >119°C (dec.)

Dichte: 1.426±0.06 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: DMSO: >10mg/mL

Aggregatzustand: white solid

pka: 8.29±0.50(Predicted)

Farbe: White to Off-White

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Sicherheit

WGK Germany	1

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GSK 1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist.

Biochem/physiol Actions

GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD (Cat. No. P8014).

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 88)Lieferanten

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ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
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Creative Enzymes	1-516-855-7709	info@creative-enzymes.com	United States	8748	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

942206-85-1()Verwandte Suche:

Nitrendipin

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
(N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide
GSK1016790A
GSK101
GSK1016790A;GSK-1016790A;GSK 1016790A
CS-2774
GSK-1016790A;GSK 1016790A
Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-
N-((S)-1-(4-(((2,4-dichlorophenyl)sulfonyl)-L-seryl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxamide
GSK1016790A(GSK101)
inhibit,Ca2+ channels,Inhibitor,embryonic,GSK-1016790A,Ca channels,HEK,vanilloid,transient,potential,receptor,TRP Channel,GSK1016790A,kidney,Calcium Channel,human,Transient receptor potential channels
942206-85-1
C28H32Cl2N4O6S2