ChemicalBook > Produktkatalog >Aktive pharmazeutische Wirkstoffe (APIs) >Antineoplastische Mittel >Natürliche antineoplastische Arzneimittel >Rubitecan

Rubitecan

91421-42-0

CAS-Nr.: 91421-42-0

Englisch Name:: Rubitecan

Synonyma:: 9-NC;RFS 2000;Oratheci;orathecin;RUBITECAN;RUBETICAN;Rubitecane;9-NITRO-CPT;9-Nitrocamptothecin;Rubitecan USP/EP/BP

CBNumber:: CB9270138

Summenformel:: C20H15N3O6

Molgewicht:: 393.35

MOL-Datei:: 91421-42-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 186

Rubitecan Eigenschaften

Schmelzpunkt:: 182-186°C

alpha: D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)

Siedepunkt:: 816.3±65.0 °C(Predicted)

Dichte: 1.63

Flammpunkt:: 106℃

storage temp.: Sealed in dry,Room Temperature

Löslichkeit: DMSO, Chloroform, Methanol

Aggregatzustand: Solid

pka: 11.16±0.20(Predicted)

Farbe: Yellow

Merck: 14,8288

CAS Datenbank: 91421-42-0(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	UQ0493300
HS Code	29399990

Rubitecan Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC₅₀s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC₅₀s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.

Chemische Eigenschaften

Yellow Amorphous Powder

Definition

ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

Rubitecan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Rubitecan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 186)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

91421-42-0()Verwandte Suche:

(+)-Camptothecin Hyoscyamin Cevadin 4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat Stickstoffdioxid

9-Nitrocamptothecin (Rubitecan)
9-Nitrocamptothecin
RFS 2000
9-Nitrocellulose camptothecine
9-NITRO-CPT
9-NITRO-20(S)-CAMPTOTHECIN
(4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
RUBETICAN
RUBITECAN
orathecin
CAMPTOTHECIN, 9-NITRO-20(S)-
Rubitecane
(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3,14(4H,-12H)-dione
9-NC
Oratheci
Rubitecan (RFS 2000)
9-Nitrocamptothecin>
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
Rubitecan USP/EP/BP
Camptothecin Impurity 13
CAMPTOTHECIN, 9-NITRO-20
(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
91421-42-0
C20H15N3O6
Anti-cancer & immunity
API
Intermediates & Fine Chemicals
Pharmaceuticals