CASIN
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- CAS-Nr.
- 425399-05-9
- Englisch Name:
- CASIN
- Synonyma:
- CASIN;Casin, >98%;CASIN >=98% (HPLC);Pirl1-related Compound 2;2-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol;2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol;Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-;2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol;Chemical Intermediate Safe Delivery Manufacturer Supply CAS 9000-71-9 Casein;Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib
- CBNumber:
- CB92714663
- Summenformel:
- C20H22N2O
- Molgewicht:
- 306.4
- MOL-Datei:
- 425399-05-9.mol
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CASIN Eigenschaften
- Siedepunkt:
- 577.8±50.0 °C(Predicted)
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- ≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH
- pka
- 14.76±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to very dark brown
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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CASIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC
50 = 2 μM for inhibiting actin assembly in PIP
2-stimulated actin polymerization assays). This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.
Verwenden
CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:
- to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells
- to study its effects on mice jejunum
- to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice
Biochem/physiol Actions
CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..
CASIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CASIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 69)Lieferanten
- CASIN
- 2-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol
- 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
- Casin, >98%
- Pirl1-related Compound 2
- Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
- CASIN >=98% (HPLC)
- Chemical Intermediate Safe Delivery Manufacturer Supply CAS 9000-71-9 Casein
- 2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol
- Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib
- 425399-05-9
