Ergotamintartrat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Ergotamine and ergometrine belong to two kinds of ergot alkaloids. Ergot (Claviceps
purpurea, 麦角) is the sclerotium of ergot fungus that grows in the rye and related
cereal and forage plants. The ergot is grown in the northeast and north China and
Xinjiang, Jiangsu, Zhejiang, Sichuan, and other places. At present, the method of
growth of ergot is inoculation cultivation.
Traditional Chinese medicine believes that ergot is tasteless, tepid, toxic, liver
meridian, and kidney meridian. The traditional usage of ergot is oral administration
of extractum, 2–4 ml each time, daily amount of 6–8 ml. Its dosage forms also contain
infusion, pills, injection, etc. Pharmacology of Chinese Medicine records ergot
can be used for uterine contraction, uterine bleeding, and postpartum hemorrhage
after delivery, incomplete recovery of uterus, retrogression, etc. The Plateau
Chinese herbal medicine treatment manual records that ergot can cure migraine.
Chemische Eigenschaften
Ergotamine tartrate is a crystalline solid.
Physikalische Eigenschaften
Appearance: White or slightly yellow fine crystalline powder with slight hygroscopicity.
Solubility: Slightly soluble in water and ethanol, insoluble in ether and
chloroform.
Verwenden
Antimigraine.
Indications
Ergometrine maleate is used in the form of extract tumor injection. As a uterotonic,
ergometrine maleate is mainly used for the prevention and treatment of uterine
bleeding caused by weak or poor uterine contraction after delivery or abortion, as
well as the incomplete recovery of postpartum uterus to accelerate the recovery of
uterus.
Ergotamine tartrate is used for the treatment of migraine in the form of tablet and
parenteral solution. It also can be used for other neurogenic headache as well.
Allgemeine Beschreibung
Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. . When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].
Health Hazard
High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.
Brandgefahr
When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat
Clinical Use
Ergonovine maleate is mainly used for the prevention and treatment of the weak
uterine contraction or poor contraction caused by uterine bleeding after delivery or
abortion. It is also used for incomplete recovery of postpartum uterus to accelerate
the recovery of the uterus.
Ergotamine tartrate is mainly used for the treatment of migraine by relieving the
symptoms. However, it is only suitable for short-term usage of headache attacks,
normally does not prevent migraine. The combination of ergotamine tartrate and
caffeine is better than single oral administration with the mild side effects. It also
can be used for other neurogenic headaches.
Sicherheitsprofil
Poison by ingestion,
intravenous, and subcutaneous routes. An
experimental teratogen. Human systemic
effects by ingestion: hallucinations, dstorted
perceptions, convulsions, nausea or
vomiting, blood pressure elevation.
Experimental reproductive effects. Human
mutation data reported. Used in production
of drugs of abuse. When heated to
decomposition it emits toxic fumes of NOx.
See also ERGOT.
mögliche Exposition
(Toxicity evaluation); Suspected
reprotoxic hazard, Suspected of causing genetic defects.
The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine
headaches. May be used in the production of “street” drugs
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required
läuterung methode
It crystallises from MeOH. [Beilstein 25 III/IV 964.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, light, and heat
Ergotamintartrat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
