Ergotamintartrat

ERGOTAMINE TARTRATE Struktur
379-79-3
CAS-Nr.
379-79-3
Bezeichnung:
Ergotamintartrat
Englisch Name:
ERGOTAMINE TARTRATE
Synonyma:
ergomar;ergostat;etin;ergam;ergate;exmigra;lingran;secagyn;secupan;femergin
CBNumber:
CB9279489
Summenformel:
C70H76N10O16
Molgewicht:
1313.41
MOL-Datei:
379-79-3.mol

Ergotamintartrat Eigenschaften

Schmelzpunkt:
~195 °C (dec.)(lit.)
alpha 
D25 -125 to -155° (c = 0.4 in chloroform)
storage temp. 
2-8°C
Merck 
13,3696
BRN 
6173437
CAS Datenbank
379-79-3(CAS DataBase Reference)
EPA chemische Informationen
Ergotamine tartrate (379-79-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 23/24/25-62-63
S-Sätze: 36/37-45
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS-Nr. KE8225000
3-8-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29396200
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P403+P233 An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

Ergotamintartrat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Ergotamine and ergometrine belong to two kinds of ergot alkaloids. Ergot (Claviceps purpurea, 麦角) is the sclerotium of ergot fungus that grows in the rye and related cereal and forage plants. The ergot is grown in the northeast and north China and Xinjiang, Jiangsu, Zhejiang, Sichuan, and other places. At present, the method of growth of ergot is inoculation cultivation.
Traditional Chinese medicine believes that ergot is tasteless, tepid, toxic, liver meridian, and kidney meridian. The traditional usage of ergot is oral administration of extractum, 2–4 ml each time, daily amount of 6–8 ml. Its dosage forms also contain infusion, pills, injection, etc. Pharmacology of Chinese Medicine records ergot can be used for uterine contraction, uterine bleeding, and postpartum hemorrhage after delivery, incomplete recovery of uterus, retrogression, etc. The Plateau Chinese herbal medicine treatment manual records that ergot can cure migraine.

Chemische Eigenschaften

Ergotamine tartrate is a crystalline solid.

Physikalische Eigenschaften

Appearance: White or slightly yellow fine crystalline powder with slight hygroscopicity. Solubility: Slightly soluble in water and ethanol, insoluble in ether and chloroform.

Verwenden

Antimigraine.

Indications

Ergometrine maleate is used in the form of extract tumor injection. As a uterotonic, ergometrine maleate is mainly used for the prevention and treatment of uterine bleeding caused by weak or poor uterine contraction after delivery or abortion, as well as the incomplete recovery of postpartum uterus to accelerate the recovery of uterus.
Ergotamine tartrate is used for the treatment of migraine in the form of tablet and parenteral solution. It also can be used for other neurogenic headache as well.

Allgemeine Beschreibung

Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. . When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].

Health Hazard

High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.

Brandgefahr

When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat

Clinical Use

Ergonovine maleate is mainly used for the prevention and treatment of the weak uterine contraction or poor contraction caused by uterine bleeding after delivery or abortion. It is also used for incomplete recovery of postpartum uterus to accelerate the recovery of the uterus.
Ergotamine tartrate is mainly used for the treatment of migraine by relieving the symptoms. However, it is only suitable for short-term usage of headache attacks, normally does not prevent migraine. The combination of ergotamine tartrate and caffeine is better than single oral administration with the mild side effects. It also can be used for other neurogenic headaches.

Sicherheitsprofil

Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: hallucinations, dstorted perceptions, convulsions, nausea or vomiting, blood pressure elevation. Experimental reproductive effects. Human mutation data reported. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx. See also ERGOT.

mögliche Exposition

(Toxicity evaluation); Suspected reprotoxic hazard, Suspected of causing genetic defects. The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine headaches. May be used in the production of “street” drugs

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

läuterung methode

It crystallises from MeOH. [Beilstein 25 III/IV 964.]

Inkompatibilitäten

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, light, and heat

Ergotamintartrat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ergotamintartrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 0)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate

  • (5α)-12'-Hydroxy-2'-Methyl-5'-(phenylMethyl)-ergotaMan-3',6',18-trione (2R,3R)-2,3-Dihydroxybutanedioate
  • ergotaMine tertrate dihydrate
  • L-Ascorbic acid,L-Threoascorbic acid, Antiscorbutic factor, VitaminC
  • ERGOTAMINE TARTRATE (ERGOT ALKALOIDW/BRO AD RANGE OF PHYS
  • ERGOTAMIN D-TARTRAT 97%
  • Ergotamine Tartrate (150 mg) (List Chemical)
  • -,[theta-(theta,theta)]-2,3-dihydroxybutanedioate(2:1)(salt)
  • 6’,18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-ergotaman-3(5’alpha)
  • ergam
  • ergate
  • ergotaminebitartrate
  • ergotartrate
  • etin
  • exmigra
  • femergin
  • gotaminetartrate
  • gynergen
  • lingraine
  • lingran
  • neo-ergotin
  • rigetamin
  • secagyn
  • secupan
  • ERGOTAMINE TARTRATE
  • ERGOTAMINE D-TARTRATE, PH EUR
  • Ergotaman-3,6,18-trione, 12-hydroxy-2-methyl-5-(phenylmethyl)-, (5.alpha.)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt)
  • ERGOTAMINETARTRATE(CONTROLLEDCHEMICAL)
  • ERGOTAMINETARTRATE,USP
  • 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3',6',18-trione deriv.
  • Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'a)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)
  • Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt)
  • Ergotamine tartrate (7CI)
  • Ergotamine, tartrate (2:1) (salt) (8CI)
  • Ergotartrat
  • Gynergin
  • Indolo[4,3-fg]quinoline, ergotaman-3',6',18-trione deriv.
  • NSC 41869
  • KEFALGIN(R)
  • (5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-Ergotaman-3',6',18-trione, [R-(R*,R*)]-2,3-dihydroxybutanediate (2:1) (salt)
  • Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)
  • gotamine
  • Medihaler-ergotamine
  • (6aR,9R)-N-((2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 2,3-dihydroxysuccinate
  • bis[(6aR,9R)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2- methyl-3,6-dioxo-octahydro-8H-oxazolo[3,2-a]pyrrolo[2,1- c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3- fg]quinoline-9-carboxamide] tartrate
  • ERGOTAMINE TARTRATE USP/EP/BP
  • ergomar
  • ergostat
  • 379-79-3
  • C33H35N5O505C4H6O6
  • C70H76N10O16
  • C37H41N5O11
  • 2C33H35N5O5C4H6O6
  • C66H70N10O10C4H6O6
  • C4H6O6C33H35N5O5
  • Heterocyclic Building Blocks
  • Others
  • Chiral Building Blocks
  • Asymmetric Synthesis
Copyright 2019 © ChemicalBook. All rights reserved