Naphtho[2,3-c]furan-1,3-dion
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- CAS-Nr.
- 716-39-2
- Bezeichnung:
- Naphtho[2,3-c]furan-1,3-dion
- Englisch Name:
- 2,3-Naphthalenedicarboxylic Anhydride
- Synonyma:
- EA253;2,3-NAPHTHALI;2,3-NAPHTHALIC ANHYDRIDE;naphtho[2,3-c]furan-1,3-dione;benzo[f][2]benzofuran-1,3-dione;benzo[f]isobenzofuran-1,3-quinone;2,3-Napthalenedicarboxycanhydride;2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE;2,3-NaphthalenedicarboxylicAnhydride>1,3-Dihydronaphtho[2,3-c]furan-1,3-dione
- CBNumber:
- CB9286597
- Summenformel:
- C12H6O3
- Molgewicht:
- 198.17
- MOL-Datei:
- 716-39-2.mol
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Naphtho[2,3-c]furan-1,3-dion Eigenschaften
- Schmelzpunkt:
- 246 °C
- Siedepunkt:
- 275-280 °C(Press: 100 Torr)
- Dichte
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Pale Beige
- Stabilität:
- Moisture Sensitive
- InChI
- InChI=1S/C12H6O3/c13-11-9-5-7-3-1-2-4-8(7)6-10(9)12(14)15-11/h1-6H
- InChIKey
- IZJDCINIYIMFGX-UHFFFAOYSA-N
- SMILES
- O1C(=O)C2=CC3C(C=C2C1=O)=CC=CC=3
- EPA chemische Informationen
- Naphtho[2,3-c]furan-1,3-dione (716-39-2)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitsschädlich bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Naphtho[2,3-c]furan-1,3-dion Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
A few years ago, the product was still synthesized from the corresponding diacid, but in recent years, it has been difficult to find the shadow of the diacid in the market, and the sales of this product have been repeatedly restricted, resulting in high prices.
Verwenden
2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
synthetische
Add anhydrous tetrahydrofuran (its mass ratio to maleic anhydride is 1.5:1), cat-1 (0.05 mole), maleic anhydride (1 mole), and o-phthalaldehyde (1.5 mole) to the reactor. After adding triethylamine (5 moles), adjust the temperature below -40°C. Silicon tetrachloride (4 moles) was added dropwise to the reaction system and the reaction was placed at -40 °C for 4 h. The mixture was heated to reflux for 20 h. After the end of the reaction, concentrating the solution to a certain concentration with diatomaceous earth filtration. A light yellow solid, namely 2,3-Naphthalenedicarboxylic Anhydride, is obtained by precipitation, filtration, recrystallization and drying. Its yield reaches 88%.
Naphtho[2,3-c]furan-1,3-dion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Naphtho[2,3-c]furan, 1,3-dihydro-
4,9-Epoxybenz[f]isobenzofuran-1,3-dione, 3a,4,9,9a-tetrahydro-
7,12-Dihydrobenz[a]anthracene
2-Naphthalenecarboxaldehyde, 3-(2-formylphenyl)-
Isobenzofuran, 1-ethoxy-1,3-dihydro-
α,α,α',α'-Tetrabrom-o-xylol
Naphthalin-2,3-dicarbonsure
Benz[a]anthracen
1,2-Benzoldicarboxaldehyd
Thionyldichlorid
Maleinsäureanhydrid
Downstream Produkte
Naphtho[2,3-c]furan-1,3-dion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 151)Lieferanten
716-39-2(Naphtho[2,3-c]furan-1,3-dion)Verwandte Suche:
6-Brom-1H,3H-naphtho[1,8-cd]pyran-1,3-dion
Naphthalin-1,8-dicarbonsureanhydrid
4-chlornaphthalin-1,8-dicarbonanhydrid
Naphtho[2,3-c]furan-1,3-dion
4-Aminonaphthalin-1,8-dicarbonsaeureanhydrid
6-Nitro-1H,3H-naphtho[1,8-cd]pyran-1,3-dion
- 2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE
- 1,3-Dihydronaphtho[2,3-c]furan-1,3-dione
- benzo[f][2]benzofuran-1,3-dione
- benzo[f]isobenzofuran-1,3-quinone
- 2,3,NAPHTHALENEDICARBOXYLIC ACIDANHYDRIDE
- naphtho[2,3-c]furan-1,3-dione
- 2,3-NAPHTHALIC ANHYDRIDE
- 2,3-NAPHTHALI
- 2,3-NaphthalenedicarboxylicAnhydride>
- 2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE ISO 9001：2015 REACH
- EA253
- 2,3-Napthalenedicarboxycanhydride
- 716-39-2
- Exciton Chirality CD Method (for Primary Amino Groups)
- Enantiomer Excess & Absolute Conefiguration Determination
- Absolute Conefiguration Determination (Exciton Chirality CD Method)
- Absolute Configuration Determination (Exciton Chirality CD Method)
- Analytical Chemistry
- Enantiomer Excess & Absolute Configuration Determination
- Exciton Chirality CD Method (for Primary Amino Groups)
