Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
Replication protein A2 (RPA32) is encoded by the gene mapped to human chromosome 1p35.3. It is a subunit of the heterotrimeric replication protein A (RPA) complex.
Biochem/physiol Actions
Replication Protein A (RPA) binds single-stranded DNA and plays a vital role in DNA replication, DNA repair, and checkpoint signaling. Phosphorylation of replication protein A2 (RPA32) by ataxia telangiectasia and Rad3-related protein kinase (ATR) and DNA-dependent protein kinase (DNA-PK) causes checkpoint kinase 1 (Chk1) activation and replication arrest. DNA-PK and ATR signaling via RPA32 (S4/S8) enhances genome stability and cell survival following replication stress.
Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
