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Entrectinib Produkt Beschreibung

Entrectinib Struktur
1108743-60-7
CAS-Nr.
1108743-60-7
Englisch Name:
Entrectinib
Synonyma:
CS-1589;NMS-E628;RXDX-101;Entrectinib;entrecitinib;Entrectinib(NMS-E628);Entrectinib(RXDX-101);Entrectinib,NMS-E628,RXDX-101;NMS E628; RXDX-101;NMSE628; RXDX 101;NMS-E628; RXDX101;RXDX101; RXDX 101; RXDX-101; NMS E628; NMSE628; NMS-E628; ENTRECTINIB
CBNumber:
CB93040787
Summenformel:
C31H34F2N6O2
Molgewicht:
560.64
MOL-Datei:
1108743-60-7.mol

Entrectinib Eigenschaften

Siedepunkt:
717.5±60.0 °C(Predicted)
Dichte
1.340±0.06 g/cm3(Predicted)
pka
12.01±0.43(Predicted)

Sicherheit

Entrectinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Entrectinib (RXDX-101, Ignyta Pharmaceuticals, San Diego, CA, USA) is a small molecule that inhibits the tyrosine kinases TRKA/B/C, ROS1, and ALK (Table?1). It has a preclinical median inhibitory concentration (IC50) of 7?nm against ROS1, higher than crizotinib [95, 96]. Entrectinib was specifically designed to cross the blood-brain barrier [95].

Clinical Use

Entrectinib demonstrated potent antitumor effects in tumor cell lines and patient-derived xenograft (PDX) tumor models in preclinical studies. Furthermore, entrectinib can cross the blood–brain barrier (BBB) to impact primary brain tumors and brain metastases in patients with NTRK1/ NTRK2/NTRK3, ROS1, and ALK fusion-driven cancers.

Entrectinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Entrectinib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 129)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shanghai Payne Pharmaceutical Technology Co.Ltd
18678586262 021-58123769
info@paynepharm.com China 1355 58
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

  • N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide
  • Entrectinib
  • Entrectinib(NMS-E628)
  • N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide
  • RXDX-101
  • Entrectinib,NMS-E628,RXDX-101
  • entrecitinib
  • Entrectinib(RXDX-101)
  • NMS-E628
  • CS-1589
  • NMS E628; RXDX-101;NMSE628; RXDX 101;NMS-E628; RXDX101
  • RXDX101; RXDX 101; RXDX-101; NMS E628; NMSE628; NMS-E628; ENTRECTINIB
  • Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-
  • 1108743-60-7
  • C31H34F2N6O2
  • API
  • API
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