Loteprednol etabonate

Loteprednol etabonate Struktur
82034-46-6
CAS-Nr.
82034-46-6
Englisch Name:
Loteprednol etabonate
Synonyma:
Etabonate;Alrex;HGP 1;P 5604;Lotemax;CDDD 5604;Etocloteprednol;LOTEPREDNOL ETABONATE;Lotoprednol etabonate;Loteprednol Impurity 10
CBNumber:
CB9396463
Summenformel:
C24H31ClO7
Molgewicht:
466.95
MOL-Datei:
82034-46-6.mol

Loteprednol etabonate Eigenschaften

Schmelzpunkt:
220.5-223.5
Siedepunkt:
600.1±55.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO: soluble5mg/mL, clear (warmed)
Aggregatzustand
powder
pka
14.06±0.70(Predicted)
Farbe
white to beige
Wasserlöslichkeit
<1mg/L(23 ºC)
Stabilität:
Hygroscopic
InChIKey
DMKSVUSAATWOCU-ICASLIHPSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2937.22.0000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H413 Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 4
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

Loteprednol etabonate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Loteprednol etabonate was introduced in the US as Lotemax (opththalmic suspension at 0.5%) for the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the ocular globe, and as Alrex (opththalmic suspension at 0.2%) for the symptomatic treatment of seasonal allergic conjunctivitis. Loteprednol etabonate is a novel soft corticosteroid with a superior efficacy and an improved safety profile compared to prior ophthalmic steroids due to its metabolic lability and a fast enzymatic transformation to inactive metabolite. A combination of Lotemax with the antibiotic Tobramycin is currently under development.

Chemische Eigenschaften

x

Verwenden

Biological Activity Chemical Information Tech Support & FAQs Biological Activity Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology. It is used for the treatment of steroid responsive inflammatory conditions of the eye su

Allgemeine Beschreibung

Loteprednol etabonate,chloromethyl 17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (Alrex,Lotemax), has a modified carboxylate at the C17 positionrather than the typical ketone functionality. This modificationmaintains affinity for the GR but allows facile metabolismto inactive metabolites. This limits the systemic actionof the drug. Loteprednol etabonate is used as anophthalmic suspension that has greatly reduced systemicaction because of rapid metabolism to the inactive carboxylate.

Loteprednol etabonate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Loteprednol etabonate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 343)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
ericqiao@jnchsd.com CHINA 158 58
Jinan Jianfeng Chemical Co., Ltd
+8615562555968
info@pharmachemm.com China 246 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 491 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14336 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58

82034-46-6()Verwandte Suche:


  • LOTEPREDNOL ETABONATE
  • Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11b,17a)-
  • Lotemax
  • 17α-(Ethoxycarbonyloxy)-11β-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester
  • 17α-(Ethoxycarbonyloxy)-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid chloromethyl ester
  • 3-Oxo-11β-hydroxy-17α-(ethoxycarbonyloxy)androsta-1,4-diene-17-carboxylic acid chloromethyl ester
  • Lotoprednol etabonate
  • CDDD-5604, HGP-1, P-5604, Alrex, Lotemax
  • Androsta-1,4-diene-17-carboxylicacid,17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-,chloromethylester,
  • chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-17-carboxylate
  • (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic Acid ChloroMethyl Ester
  • (11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-Androsta-1,4-diene-17-carboxylic acid chloromethyl ester
  • CDDD 5604
  • HGP 1
  • P 5604
  • (11β,17α)-7-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic acid chloromethyl ester
  • Loteprednol etabonate, >=99%
  • Loteprednol etabonate WS
  • 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester
  • Loteprednol Impurity 10
  • Loteprednol Etabonate| Etabonate
  • Loteprednol etabonate,100ppm
  • Loteprednol etabonate,HGP 1
  • Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-
  • Loteprednol etabonate Solution, 100μg/mL
  • (8S,9S,10R,11S,13S,14S,17S)-Chloromethyl 17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
  • (11beta,17alpha)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Chloromethyl Ester
  • Chloromethyl (11beta,17alpha)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
  • Loteprednol Etabonate(Micronized)
  • Loteprednol etabonate USP/EP/BP
  • Loteprednol EtabonateQ: What is Loteprednol Etabonate Q: What is the CAS Number of Loteprednol Etabonate Q: What is the storage condition of Loteprednol Etabonate
  • Etabonate
  • Alrex
  • Etocloteprednol
  • (8S,9S,10R,11S,13S,14S,17R)-chloromethyl 17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
  • 82034-46-6
  • 82304-46-6
  • C24H31ClO7
  • C24H31O7CL
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Alrex, Lotemax
  • Hormone Drugs
  • APIs
  • Steroid and Hormone
  • API
  • 82034-46-6
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