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N-Fluoren-2-ylacetamid Produkt Beschreibung

2-ACETAMIDOFLUORENE Struktur
53-96-3
CAS-Nr.
53-96-3
Bezeichnung:
N-Fluoren-2-ylacetamid
Englisch Name:
2-ACETAMIDOFLUORENE
Synonyma:
AAF;2-AAF;2-FAA;faa[qr];aaf[qr];2-aaf[qr];2-faa[qr];NSC 12279;N-2-Fluorenyl;Acetamidofluorene
CBNumber:
CB9463907
Summenformel:
C15H13NO
Molgewicht:
223.27
MOL-Datei:
53-96-3.mol

N-Fluoren-2-ylacetamid Eigenschaften

Schmelzpunkt:
192-196 °C(lit.)
Siedepunkt:
364.56°C (rough estimate)
Dichte
1.0707 (rough estimate)
Brechungsindex
1.5500 (estimate)
storage temp. 
Store below +30°C.
Löslichkeit
Soluble in acetone, acetic acid, alcohol (Weast, 1986), glycols, and fat solvents (Windholz et al., 1983)
Aggregatzustand
Crystalline Powder
Farbe
off-white to tan
Wasserlöslichkeit
10.13 mg/L at 26.3 °C (Ellington et al., 1987)
Merck 
14,4157
BRN 
2807677
CAS Datenbank
53-96-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,N
R-Sätze: 45-22-51/53
S-Sätze: 53-36/37/39-45
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS-Nr. AB9450000
HS Code  2924 29 70
HazardClass  6.1(b)
PackingGroup  III
Toxizität Acute oral LD50 for mice 1,020 mg/kg (quoted, RTECS, 1985).
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H350 Kann Krebs verursachen. Karzinogenität Kategorie 1A Achtung
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

N-Fluoren-2-ylacetamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

WHITE TO YELLOW-BROWN CRYSTALLINE POWDER

Chemische Eigenschaften

2-Acetylaminofluorene (AAF) is a combustible, tan powder or crystalline solid

Verwenden

As a positive control to study the carcinogenicity and mutagenicity of aromatic amines.

Definition

ChEBI: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.

Allgemeine Beschreibung

White powder or light beige solid.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

2-ACETAMIDOFLUORENE is incompatible with acids, bases and oxidizing agents. Ozone and chlorinating agents oxidize 2-ACETAMIDOFLUORENE .

Brandgefahr

Flash point data for 2-ACETAMIDOFLUORENE are not available; however, 2-ACETAMIDOFLUORENE is probably combustible.

Sicherheitsprofil

Confirmed human carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

mögliche Exposition

2-AAF was intended to be used as a pesticide, but it was never marketed because this chemical was found to be carcinogenic. AAF is used frequently by biochemists and technicians engaged in the study of liver enzymes and the carcinogenicity and mutagenicity ofaromatic amines as a positive control. Therefore, these persons may be exposed to AAF.

Carcinogenicity

2-Acetylaminofluorene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Biological. In the presence of suspended natural populations from unpolluted aquatic systems, the second-order microbial transformation rate constant determined in the laboratory was reported to be 4.8 ± 2.8 x 10-12 L/organism?h (Steen, 1991).
Chemical/Physical. Based on first-order rate constants determined at 85.5 °C, hydrolysis halflives at pH values of 2.49, 2.97, 7.34, 9.80, 10.25, and 10.39 were 4.2, 12, 41, 13, 7.2, and 1.9 d, respectively (Ellington et al., 1987). Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).

Versand/Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

läuterung methode

Recrystallise it from toluene (1.3mg in 100mL). Its solubility in H2O is 1.3mg/L at 25o, UV: max nm(log ) : 288(4.43), 313(4.13). [Sawicki J Org Chem 21 271 1956.] It can also be recrystallised from 50% AcOH. [Diels et al. Chem Ber 35 3285 1902]. 9-14C and -14C 2-acetamidofluorene were recrystallised from aqueous EtOH and had m 194-195o and 194o respectively. Potent CARCINOGEN. [Miller et al. Cancer Res 9 504 1949, 10 616 1950, Sadin et al. J Am Chem Soc 74 5073 1952, Beilstein 12 H 3287, 12 IV 3373.]

Inkompatibilitäten

Hygroscopic. Contact with strong oxidizers may cause fire and explosions. Not compatible with cyanides, acids, and/or acid anhydrides. May form unstable and explosive peroxides; a possible polymerization hazard. Contact with strong oxidizers or strong reducing agents may form flammable gases and cause fire and explosions. A weak base that may react as an acid. Incompatible with strong bases (forming potentially dangerous salts), chlorinated hydrocarbons, nitro compounds. Reacts with azo and diazo compounds, generating toxic gases. Contact with mixture of acetic acid 1 dinitrogen trioxide may cause explosion.

Waste disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Presumably high-temperature incineration with scrubber for any produced nitrogen oxides can be used

Verordnung (Regulations)

Environmental Protection Agency (EPA)
Clean Air Act
National Emissions Standards for Hazardous Air Pollutants: Listed as a hazardous air pollutant.
Comprehensive Environmental Response, Compensation, and Liability Act Reportable quantity (RQ) = 1 lb.
Emergency Planning and Community Right-To-Know Act
Toxics Release Inventory: Listed substance subject to reporting requirements.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of 2-acetylaminofluorene = U005. Listed as a hazardous constituent of waste.
Mine Safety and Health Administration
To control airborne exposure, 2-acetylaminofluorene shall not be used or stored except by competent persons under laboratory conditions approved by a nationally recognized agency acceptable to the Secretary.
Occupational Safety and Health Administration (OSHA)
Potential occupational carcinogen: Engineering controls, work practices, and personal protective equipment are required.

N-Fluoren-2-ylacetamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-Fluoren-2-ylacetamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 92)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40269 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44025 61
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13010 57
BEST-REAGENT 400-1166-196 18981987031
028-84555506 QQ:800101999 cdhxsj@163.com China 9900 57
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771
sales@heowns.com China 14460 57
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 mkt@spectrumchina.net China 9689 60
Chengdu Ai Keda Chemical Technology Co., Ltd. 4008-755-333 ; 028-86676798 ; 028-86757656
028-86757656 aikeshiji@163.com China 9755 55
Shanghai civi chemical technology co.,Ltd 86-21-34053660;34053661
86-21-34053661 sale@labgogo.com China 9888 52

53-96-3(N-Fluoren-2-ylacetamid)Verwandte Suche:


  • 2-AAF
  • acetylaminofluorene
  • Azetylaminofluoren
  • faa[qr]
  • N-(9H-Fluoren-2-Yl)acetamide
  • N-2-Fluorenyl
  • n-9h-fluoren-2-yl-acetamid
  • n-9h-fluoren-2-ylacetamide
  • N-Acetyl-2-aminofluorene
  • n-acetyl-2-aminofluorene[qr]
  • n-fluoren-2-yl-acetamid
  • N-(2-FLUORENYL)ACETAMIDE, >=98% (
  • N-Fluoren-2-ylacetamide for synthesis
  • 2-aaf[qr]
  • 2-acetaminofluorene[qr]
  • 2-Acetylamino-fluoren
  • 2-Acetylaminofluorine
  • 2-FAA
  • 2-faa[qr]
  • 2-Fluorenylacetamide
  • 2-fluorenylacetamide[qr]
  • AAF
  • aaf[qr]
  • Acetamide, N-9H-fluoren-2-yl-
  • Acetamide, N-fluoren-2-yl-
  • Acetoaminofluorene
  • n-fluorenyl-2-acetamide[qr]
  • Rcra waste number U005
  • rcrawastenumberu005
  • N-(FLUOREN-2-YL)-ACETAMIDE
  • N-ACETYLAMINOFLUORENE
  • N-2-FLUORENYLACETAMIDE
  • 2-ACETAMIDOFLUOREN
  • 2-ACETAMIDOFLUORENE
  • 2-ACETAMINOFLUORENE
  • 2-ACETYLAMINOFLUORENE
  • LABOTEST-BB LT00012672
  • Acetamidofluorene
  • 2-Acetamido fluorene;AAF;2-FAA;N-9H-Fluoren-2-ylacetamide;N-(2-Fluorenyl)acetamide;2-Acetylaminofluorene
  • 2-ACETAMIDOFLUORENE ISOPAC
  • N-2-ACETYLAMINOFLUORENE
  • 2-ACETAMIDOFLUOROENE
  • 2-AAF, 2-Acetamidofluorene, N-Acetyl-2-aminofluorene
  • 2-AAF, 2-Acetamidofluorene, N-(2-Fluorenyl)acetamide, N-Acetyl-2-aminofluorene
  • 2-Acetamidofluorene,95%
  • 2-AcetaMidofluorene, 95% 5GR
  • NSC 12279
  • 2-Acetylaminofluorene 〔N-2-Fluorenylacetamide〕
  • 53-96-3
  • Fluorenes
  • Fluorenes & Fluorenones
  • Cancer Research
  • Carcinogens
  • BioChemical
  • Fluorenes, Flurenones
  • Fluorenes & Fluorenones
  • Fluorenes
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