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Bivalirudin Produkt Beschreibung

Bivalirudin Struktur
128270-60-0
CAS-Nr.
128270-60-0
Englisch Name:
Bivalirudin
Synonyma:
BIVALIRUDIN;Bivalirudinum;BITTERMELONP.E;Bivalirudin, TFA;Human Bivalirudin;Bivalirudin Acetate;Bivalirudin Trifluoacetate;BG 8967, Hirulog, Hirulog I;BIVALIRUDIN TRIFLUOROACETATE;Hirulog trifluoroacetate salt
CBNumber:
CB9471951
Summenformel:
C98H138N24O33
Molgewicht:
2180.29
MOL-Datei:
128270-60-0.mol

Bivalirudin Eigenschaften

storage temp. 
?20°C
Aggregatzustand
powder
Farbe
white to off-white

Sicherheit

WGK Germany  3

Bivalirudin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bivalirudin was launched in New Zealand as an anticoagulant for i.v. treatment of patients with unstable angina undergoing percutaneous transluminal coronary angioplasty. Bivalirubin is a synthetic 20 amino acid peptide rationally modeled on hirudin (residues 53- 64), the most potent and specific naturally-occuring known inhibitor of thrombin, the enzyme that plays a key role in hemostasis and blood clot formation. This peptide is a direct thrombin inhibitor that maintains the unique bivalent binding properties of hirudin to the catalytic site and to the fibrin-recognition exosite of the enzyme, so acting directly on thrombin with high affinity and specificity. In vitro studies demonstrated that alpha- and zeta-thrombins, both with the higher fibrinogen-procoagulant activities, were inhibited. In rats receiving high doses of bivalirudin, the platelet deposition in carotide was reduced by 63% compared to controls. The results of clinical studies, conducted only in patients receiving concomitant aspirin, suggested that the use of bivalirudin was more efficacious and more predictable than unfractionated heparin, with fewer bleeding complications. Despite some unresolved developmental issues, the attractive properties of this novel agent could make it a useful alternative to heparin in a variety of coagulation disorders.

Originator

Biogen (US)

Verwenden

Anticoagulant; antithrombotic.

Definition

ChEBI: A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva o the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.

Trademarks

Angiomax (Medicinova).

Bivalirudin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bivalirudin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 194)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Cellmano Biotech Limited
+86-551-65326643
+86-551-65326641 info@cellmano.com CHINA 1044 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21675 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO., LTD.
18315825527
kevin@tianmapharma.com CHINA 19 58

128270-60-0()Verwandte Suche:


  • BIVALIRUDIN
  • BIVALIRUDIN TRIFLUOROACETATE
  • Bivalirudin, TFA
  • BITTERMELONP.E
  • Human Bivalirudin
  • Bivalirudin Acetate
  • Bivalirudin BG 8967, Hirulog, Hirulog I
  • BG 8967, Hirulog, Hirulog I
  • H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
  • H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH trifluoroacetate salt
  • Bivalirudin trifluoroacetate salt
  • D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-aspariginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine trifluoroacetate
  • Hirulog trifluoroacetate salt
  • Bivalirudin Trifluoacetate
  • Bivalirudinum
  • Bivalirudin(Bivalirudin Trifluoroacetate)
  • 128270-60-0
  • C98H138N24O33
  • Peptide
  • API
  • proteins
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