InSolution H-89, Dihydrochloride - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (K
i = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (K
i = 28.3 μM), Ca
2+/calmodulin-dependent protein kinase II (K
i = 29.7 μM), protein kinase C (K
i = 31.7 μM), casein kinase I (K
i = 38.3 μM), and Rho Kinase II (IC
50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 μM) by blocking the action of Rho kinase II.
Biochem/physiol Actions
Target Ki: 48 nM against protein kinase A
InSolution H-89, Dihydrochloride - Calbiochem Upstream-Materialien And Downstream Produkte
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